Challenges and trends in magnetic sensor integration with microfluidics for biomedical applications

被引：77

作者：

Cardoso, S. ^{[1
,2
,3
]}

Leitao, D. C. ^{[1
,2
,3
]}

Dias, T. M. ^{[1
,2
,3
]}

Valadeiro, J. ^{[1
,2
,3
]}

Silva, M. D. ^{[1
,2
,3
]}

Chicharo, A. ^{[3
,4
]}

Silverio, V. ^{[1
,2
]}

Gaspar, J. ^{[4
]}

Freitas, P. P. ^{[1
,2
,4
]}

机构：

[1] INESC, MN, Rua Alves Redol 9, P-1000029 Lisbon, Portugal

[2] IN, Rua Alves Redol 9, P-1000029 Lisbon, Portugal

[3] Univ Lisbon, Inst Super Tecn, Av Rovisco Pais, P-1049001 Lisbon, Portugal

[4] INL, Int Iberian Nanotechnol Lab, Av Mestre Jose Veiga, P-4715330 Braga, Portugal

来源：

JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2017年 / 50卷 / 21期

基金：

欧盟第七框架计划;

关键词：

magnetoresistive sensors; microfluidics; superparamagnetic nanoparticles; lateral flow devices; flexible electronics; microelectrodes; biochips; SPIN-VALVE SENSORS; DENSITY ELECTRODE ARRAY; FLEXIBLE NEURAL PROBES; MAGNETORESISTIVE SENSORS; GIANT MAGNETORESISTANCE; GMR SENSORS; BRAIN ACTIVITY; FABRICATION; CHIP; QUANTIFICATION;

D O I：

10.1088/1361-6463/aa66ec

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Magnetoresistive (MR) sensors have been successfully applied in many technologies, in particular readout electronics and smart systems for multiple signal addressing and readout. When single sensors are used, the requirements relate to spatial resolution and localized field sources. The integration of MR sensors in adaptable media (e.g. flexible, stretchable substrates) offers the possibility to merge the magnetic detection with mechanical functionalities. In addition, the precision of a micrometric needle can benefit greatly from the integration of MR sensors with submicrometric resolution. In this paper, we demonstrate through several detailed examples how advanced MR sensors can be integrated with the systems described above, and also with microfluidic technologies. Here, the challenges of handling liquids over a chip combine with those for miniaturization of microelectronics for MR readout. However, when these are overcome, the result is an integrated system with added functionalities, capable of answering the demand in biomedicine and biochemistry for lab-on-a-chip devices.

引用

页数：21

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