Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter (OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health Products (ANSM) of France issued a warning for NSAID uses by patients with infectious diseases based on an analysis of 20 years of real-world safety data on ibuprofen and ketoprofen. Nevertheless, ibuprofen remains a mainstay in the analgesic armamentarium and with numerous randomized clinical trials, head-to-head studies, and decades of clinical experience. The authors offer a review of the safety of ibuprofen and how it may differ from other NSAIDs. Ibuprofen is associated with certain well-known gastrointestinal adverse effects that are related to dose and patient population. Among nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen has a comparatively low risk of cardiovascular adverse effects. It has been associated with renal and hepatic adverse effects, which appear to depend on dose, concomitant medications, and patient population. The association of ibuprofen with infections is more complex in that it confers risk in some situations but benefits in others, the latter in cystic fibrosis. Emerging interest in the literature is providing evidence of the role of ibuprofen as a possible endocrine disrupter as well as its potential antiproliferative effects for cancer cells. Taken altogether, ibuprofen has a favorable safety profile and is an effective analgesic for many acute and chronic pain conditions, although it-like other NSAIDs-is not without risk. After 50 years, evidence is still emerging about ibuprofen and its unique safety profile among NSAIDs. Funding The Rapid Service Fee was funded by Abbott Established Pharmaceuticals Division (EPD).
机构:
Univ Illinois, Coll Med, Vernon Hills, IL 60061 USA
Illinois Bone & Joint Inst LLC, Glenview, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Bello, Alfonso E.
Kent, Jeffrey D.
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Horizon Pharma Inc, Med Affairs & Hlth Outcomes, Deerfield, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Kent, Jeffrey D.
Grahn, Amy Y.
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Horizon Pharma Inc, Clin Dev & Operat, Deerfield, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Grahn, Amy Y.
Rice, Patricia
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h-index: 0
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Premier Res Inc, Stat, Naperville, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Rice, Patricia
Holt, Robert J.
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Univ Illinois, Coll Pharm, Vernon Hills, IL 60061 USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Ben Maamar, Millissia
Lesne, Laurianne
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Lesne, Laurianne
Hennig, Kristin
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h-index: 0
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LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Hennig, Kristin
Desdoits-Lethimonier, Christele
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Desdoits-Lethimonier, Christele
Kilcoyne, Karen R.
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Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth Univ, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Kilcoyne, Karen R.
Coiffec, Isabelle
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Coiffec, Isabelle
Rolland, Antoine D.
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h-index: 0
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Rolland, Antoine D.
Chevrier, Cecile
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Chevrier, Cecile
Kristensen, David M.
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Ole Maaloes Vej 5, DK-2200 Copenhagen N, DenmarkUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Kristensen, David M.
Lavoue, Vincent
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Hop Sud, Serv Gynecol, CHU Rennes, 16 Blvd Bulgarie, F-35700 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Lavoue, Vincent
Antignac, Jean-Philippe
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LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Antignac, Jean-Philippe
Le Bizec, Bruno
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LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Le Bizec, Bruno
Dejucq-Rainsford, Nathalie
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Dejucq-Rainsford, Nathalie
Mitchell, Rod T.
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h-index: 0
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Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth Univ, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
机构:
Univ Illinois, Coll Med, Vernon Hills, IL 60061 USA
Illinois Bone & Joint Inst LLC, Glenview, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Bello, Alfonso E.
Kent, Jeffrey D.
论文数: 0引用数: 0
h-index: 0
机构:
Horizon Pharma Inc, Med Affairs & Hlth Outcomes, Deerfield, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Kent, Jeffrey D.
Grahn, Amy Y.
论文数: 0引用数: 0
h-index: 0
机构:
Horizon Pharma Inc, Clin Dev & Operat, Deerfield, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Grahn, Amy Y.
Rice, Patricia
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h-index: 0
机构:
Premier Res Inc, Stat, Naperville, IL USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
Rice, Patricia
Holt, Robert J.
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h-index: 0
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Univ Illinois, Coll Pharm, Vernon Hills, IL 60061 USAUniv Illinois, Coll Med, Vernon Hills, IL 60061 USA
机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Ben Maamar, Millissia
Lesne, Laurianne
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Lesne, Laurianne
Hennig, Kristin
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h-index: 0
机构:
LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Hennig, Kristin
Desdoits-Lethimonier, Christele
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Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Desdoits-Lethimonier, Christele
Kilcoyne, Karen R.
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h-index: 0
机构:
Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth Univ, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Kilcoyne, Karen R.
Coiffec, Isabelle
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h-index: 0
机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Coiffec, Isabelle
Rolland, Antoine D.
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h-index: 0
机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Rolland, Antoine D.
Chevrier, Cecile
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机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Chevrier, Cecile
Kristensen, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Ole Maaloes Vej 5, DK-2200 Copenhagen N, DenmarkUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Kristensen, David M.
Lavoue, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Hop Sud, Serv Gynecol, CHU Rennes, 16 Blvd Bulgarie, F-35700 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Lavoue, Vincent
Antignac, Jean-Philippe
论文数: 0引用数: 0
h-index: 0
机构:
LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Antignac, Jean-Philippe
Le Bizec, Bruno
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h-index: 0
机构:
LUNAM Univ, Oniris, USC INRA 1329, Lab Etud Residus & Contaminants Aliments LABERCA, F-44307 Nantes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Le Bizec, Bruno
Dejucq-Rainsford, Nathalie
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h-index: 0
机构:
Univ Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, FranceUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France
Dejucq-Rainsford, Nathalie
Mitchell, Rod T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth Univ, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Rennes 1, INSERM, UMR 1085, Irset, 9 Ave Leon Bernard, F-35000 Rennes, France