Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review

被引:103
作者
Varrassi, Giustino [1 ,2 ]
Pergolizzi, Joseph V. [3 ]
Dowling, Pascal [4 ]
Paladini, Antonella [5 ]
机构
[1] Paolo Procacci Fdn, Via Tacito 7, I-00193 Rome, Italy
[2] World Inst Pain, Winston Salem, NC USA
[3] NEMA Res Inc, Naples, FL USA
[4] Abbott Prod Operat AG, Hegenheimermattweg 127, CH-4123 Allschwil, Switzerland
[5] Univ Aquila, Dept MESVA, I-67100 Laquila, Italy
关键词
Analgesics; Cardiovascular safety; Gastrointestinal safety; Ibuprofen; NSAIDs; Safety; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; UPPER GASTROINTESTINAL COMPLICATIONS; SINGLE-TABLET IBUPROFEN/FAMOTIDINE; HYPERSENSITIVITY REACTIONS; CARDIOVASCULAR SAFETY; DOUBLE-BLIND; CYCLOOXYGENASE-2; INHIBITORS; MYOCARDIAL-INFARCTION; NECROTIZING FASCIITIS; RISK-FACTORS;
D O I
10.1007/s12325-019-01144-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter (OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health Products (ANSM) of France issued a warning for NSAID uses by patients with infectious diseases based on an analysis of 20 years of real-world safety data on ibuprofen and ketoprofen. Nevertheless, ibuprofen remains a mainstay in the analgesic armamentarium and with numerous randomized clinical trials, head-to-head studies, and decades of clinical experience. The authors offer a review of the safety of ibuprofen and how it may differ from other NSAIDs. Ibuprofen is associated with certain well-known gastrointestinal adverse effects that are related to dose and patient population. Among nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen has a comparatively low risk of cardiovascular adverse effects. It has been associated with renal and hepatic adverse effects, which appear to depend on dose, concomitant medications, and patient population. The association of ibuprofen with infections is more complex in that it confers risk in some situations but benefits in others, the latter in cystic fibrosis. Emerging interest in the literature is providing evidence of the role of ibuprofen as a possible endocrine disrupter as well as its potential antiproliferative effects for cancer cells. Taken altogether, ibuprofen has a favorable safety profile and is an effective analgesic for many acute and chronic pain conditions, although it-like other NSAIDs-is not without risk. After 50 years, evidence is still emerging about ibuprofen and its unique safety profile among NSAIDs. Funding The Rapid Service Fee was funded by Abbott Established Pharmaceuticals Division (EPD).
引用
收藏
页码:61 / 82
页数:22
相关论文
共 123 条
  • [11] Differences in cardiovascular safety with non-steroidal anti-inflammatory drug therapy-A nationwide study in patients with osteoarthritis
    Barcella, Carlo Alberto
    Lamberts, Morten
    McGettigan, Patricia
    Fosbol, Emil Loldrup
    Lindhardsen, Jesper
    Torp-Pedersen, Christian
    Gislason, Gunnar Hilmar
    Olsen, Anne-Marie Schjerning
    [J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2019, 124 (05) : 629 - 641
  • [12] Streptococcal toxic shock syndrome: a description of 14 cases from North Yorkshire, UK
    Barnham, MRD
    Weightman, NC
    Anderson, AW
    Tanna, A
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2002, 8 (03) : 174 - 181
  • [13] BBC, 2019, BBC NEWS
  • [14] Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ibuprofen in older persons
    Bello, Alfonso E.
    Kent, Jeffrey D.
    Holt, Robert J.
    [J]. PHYSICIAN AND SPORTSMEDICINE, 2015, 43 (03) : 193 - 199
  • [15] One-year safety of ibuprofen/famotidine fixed combination versus ibuprofen alone: pooled analyses of two 24-week randomized, double-blind trials and a follow-on extension
    Bello, Alfonso E.
    Grahn, Amy Y.
    Ball, Julie
    Kent, Jeffrey D.
    Holt, Robert J.
    [J]. CURRENT MEDICAL RESEARCH AND OPINION, 2015, 31 (03) : 407 - 420
  • [16] Risk of Upper Gastrointestinal Ulcers in Patients With Osteoarthritis Receiving Single-Tablet Ibuprofen/Famotidine Versus Ibuprofen Alone: Pooled Efficacy and Safety Analyses of Two Randomized, Double-Blind, Comparison Trials
    Bello, Alfonso E.
    Kent, Jeffrey D.
    Grahn, Amy Y.
    Rice, Patricia
    Holt, Robert J.
    [J]. POSTGRADUATE MEDICINE, 2014, 126 (04) : 82 - 91
  • [17] Ibuprofen results in alterations of human fetal testis development
    Ben Maamar, Millissia
    Lesne, Laurianne
    Hennig, Kristin
    Desdoits-Lethimonier, Christele
    Kilcoyne, Karen R.
    Coiffec, Isabelle
    Rolland, Antoine D.
    Chevrier, Cecile
    Kristensen, David M.
    Lavoue, Vincent
    Antignac, Jean-Philippe
    Le Bizec, Bruno
    Dejucq-Rainsford, Nathalie
    Mitchell, Rod T.
    Mazaud-Guittot, Severine
    Jegou, Bernard
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [18] Non-steroidal anti-inflammatory drugs: What is the actual risk of liver damage?
    Bessone, Fernando
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (45) : 5651 - 5661
  • [19] Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials
    Bhala, N.
    Emberson, J.
    Merhi, A.
    Abramson, S.
    Arber, N.
    Baron, J. A.
    Bombardier, C.
    Cannon, C.
    Farkouh, M. E.
    FitzGerald, G. A.
    Goss, P.
    Halls, H.
    Hawk, E.
    Hawkey, C.
    Hennekens, C.
    Hochberg, M.
    Holland, L. E.
    Kearney, P. M.
    Laine, L.
    Lanas, A.
    Lance, P.
    Laupacis, A.
    Oates, J.
    Patrono, C.
    Schnitzer, T. J.
    Solomon, S.
    Tugwell, P.
    Wilson, K.
    Wittes, J.
    Baigent, C.
    Adelowo, O.
    Aisen, P.
    Al-Quorain, A.
    Altman, R.
    Bakris, G.
    Baumgartner, H.
    Bresee, C.
    Carducci, M.
    Chang, D-M.
    Chou, C-T.
    Clegg, D.
    Cudkowicz, M.
    Doody, L.
    El Miedany, Y.
    Falandry, C.
    Farley, J.
    Ford, L.
    GarciLosa, M.
    Gonzalez-Ortiz, M.
    Haghighi, M.
    [J]. LANCET, 2013, 382 (9894) : 769 - 779
  • [20] Biskupiak Joseph E, 2006, J Pain Palliat Care Pharmacother, V20, P7, DOI 10.1300/J354v20n03_03