Incidence of brain lesions in moderate-late preterm infants assessed by cranial ultrasound and MRI: The BIMP-study

被引：17
作者：
Boswinkel, Vivian [1 ,2 ]
Kruse-Ruijter, Martine F. [1 ]
Nijboer-Oosterveld, Jacqueline [3 ]
Nijholt, Ingrid M. [3 ]
Edens, Mireille A. [4 ]
Mulder-de Tollenaer, Susanne M. [1 ]
Smit-Wu, Mei-Nga [5 ]
Boomsma, Martijn F. [3 ]
de Vries, Linda S. [6 ]
van Wezel-Meijler, Gerda [1 ]
机构：
[1] Isala Women & Childrens Hosp, Dept Neonatol, V4-4,POB 10400, NL-8000 GK Zwolle, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht Brain Ctr, Utrecht, Netherlands
[3] Isala Hosp, Dept Radiol, Zwolle, Netherlands
[4] Isala Hosp, Dept Innovat & Sci, Zwolle, Netherlands
[5] Isala Women & Childrens Hosp, Dept Pediat, Zwolle, Netherlands
[6] Univ Med Ctr Utrecht, Dept Neonatol, Utrecht, Netherlands
来源：
EUROPEAN JOURNAL OF RADIOLOGY | 2021年 / 136卷
关键词：
Moderate-late preterm infants; Cranial ultrasound; Magnetic resonance imaging; Brain lesions; Intraventricular hemorrhage; WHITE-MATTER INJURY; PREMATURE-INFANTS; NEONATAL-PERIOD; AGE; DIAGNOSIS; HEMORRHAGE; CHILDREN; BIRTH; BORN; US;
D O I：
10.1016/j.ejrad.2020.109500
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To evaluate the incidence and characteristics of brain lesions in moderate-late preterm (MLPT) infants, born at 32-36 weeks' gestation using cranial ultrasound (cUS) and magnetic resonance imaging (MRI). Methods: Prospective cohort study carried out at Isala Women and Children's Hospital between August 2017 and November 2019. cUS was performed at postnatal day 3-4 (early-cUS), before discharge and repeated at term equivalent age (TEA) in MLPT infants born between 32(+0) and 35(+6) weeks' gestation. At TEA, MRI was also performed. Several brain lesions were assessed e.g. hemorrhages, white matter and deep gray matter injury. Brain maturation was visually evaluated. Lesions were classified as mild or moderate-severe. Incidences and confidence intervals were calculated. Results: 166 MLPT infants were included of whom 127 underwent MRI. One or more mild lesions were present in 119/166 (71.7 %) and moderate-severe lesions in 6/166 (3.6 %) infants on cUS and/or MRI. The most frequent lesions were signs suggestive of white matter injury: inhomogeneous echogenicity in 50/164 infants (30.5 %) at early-cUS, in 12/148 infants (8.1 %) at TEA-cUS and diffuse white matter signal changes (MRI) in 27/127 (23.5 %) infants. Cerebellar hemorrhage (MRI) was observed in 16/127 infants (12.6 %). Delayed maturation (MRI) was seen in 17/117 (13.4 %) infants. Small hemorrhages and punctate white matter lesions were more frequently detected on MRI than on cUS. Conclusions: In MLPT infants mild brain lesions were frequently encountered, especially signs suggestive of white matter injury and small hemorrhages. Moderate-severe lesions were less frequently seen.
引用
收藏
页数：11
相关论文
共 39 条
[11]   THE SPECTRUM OF LEUKOMALACIA USING CRANIAL ULTRASOUND [J].
DEVRIES, LS ;
EKEN, P ;
DUBOWITZ, LMS .
BEHAVIOURAL BRAIN RESEARCH, 1992, 49 (01) :1-6
[12]   Differential diagnosis of intracranial cystic lesions at head US:: Correlation with CT and MR imaging [J].
Epelman, Monica ;
Daneman, Alan ;
Blaser, Susan I. ;
Ortiz-Neira, Clara ;
Konen, Osnat ;
Jarrin, Jose ;
Navarro, Oscar M. .
RADIOGRAPHICS, 2006, 26 (01) :173-U239
[13]   Cranial ultrasound findings in late preterm infants and correlation with perinatal risk factors [J].
Fumagalli, Monica ;
Ramenghi, Luca Antonio ;
De Carli, Agnese ;
Bassi, Laura ;
Fare, Pietro ;
Dessimone, Francesca ;
Pisoni, Silvia ;
Sirgiovanni, Ida ;
Groppo, Michela ;
Ometto, Alessandra ;
Consonni, Dario ;
Triulzi, Fabio ;
Mosca, Fabio .
ITALIAN JOURNAL OF PEDIATRICS, 2015, 41
[14]   Cerebral measurements made using cranial ultrasound in term Ugandan newborns [J].
Hagmann, C. F. ;
Robertson, N. J. ;
Acolet, D. ;
Nyombi, N. ;
Ondo, S. ;
Nakakeeto, M. ;
Cowan, F. M. .
EARLY HUMAN DEVELOPMENT, 2011, 87 (05) :341-347
[15]   Ultrasound diagnosis of brain atrophy is related to neurodevelopmental outcome in preterm infants [J].
Horsch, S ;
Muentjes, C ;
Franz, A ;
Roll, C .
ACTA PAEDIATRICA, 2005, 94 (12) :1815-1821
[16]   Developmental Delay in Moderately Preterm-Born Children at School Entry [J].
Kerstjens, Jorien M. ;
de Winter, Andrea F. ;
Bocca-Tjeertes, Inger F. ;
ten Vergert, Elisabeth M. J. ;
Reijneveld, Sijmen A. ;
Bos, Arend F. .
JOURNAL OF PEDIATRICS, 2011, 159 (01) :92-98
[17]   New MR Imaging Assessment Tool to Define Brain Abnormalities in Very Preterm Infants at Term [J].
Kidokoro, H. ;
Neil, J. J. ;
Inder, T. E. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2013, 34 (11) :2208-2214
[18]   Prevalence and Risk Factors of Incidental Findings in Brain MRIs of Healthy Neonates-The FinnBrain Birth Cohort Study [J].
Kumpulainen, Venla ;
Lehtola, Satu J. ;
Tuulari, Jetro J. ;
Silver, Eero ;
Copeland, Anni ;
Korja, Riikka ;
Karlsson, Hasse ;
Karlsson, Linnea ;
Merisaari, Harri ;
Parkkola, Riitta ;
Saunavaara, Jani ;
Lahdesmaki, Tuire ;
Scheinin, Noora M. .
FRONTIERS IN NEUROLOGY, 2020, 10
[19]   Is sequential cranial ultrasound reliable for detection of white matter injury in very preterm infants? [J].
Leijser, Lara M. ;
de Bruine, Francisca T. ;
van der Grond, Jeroen ;
Steggerda, Sylke J. ;
Walther, Frans J. ;
van Wezel-Meijler, Gerda .
NEURORADIOLOGY, 2010, 52 (05) :397-406
[20]   Brain imaging findings in very preterm infants throughout the neonatal period: Part I. Incidences and evolution of lesions, comparison between ultrasound and MRI [J].
Leijser, Lara M. ;
Bruine, Francisca T. de ;
Steggerda, Sylke J. ;
van der Grond, Jeroen ;
Walther, Frans J. ;
van Wezel-Meijler, Gerda .
EARLY HUMAN DEVELOPMENT, 2009, 85 (02) :101-109
1234