Incidence of brain lesions in moderate-late preterm infants assessed by cranial ultrasound and MRI: The BIMP-study

被引：10
作者：
Boswinkel, Vivian [1 ,2 ]
Kruse-Ruijter, Martine F. [1 ]
Nijboer-Oosterveld, Jacqueline [3 ]
Nijholt, Ingrid M. [3 ]
Edens, Mireille A. [4 ]
Mulder-de Tollenaer, Susanne M. [1 ]
Smit-Wu, Mei-Nga [5 ]
Boomsma, Martijn F. [3 ]
de Vries, Linda S. [6 ]
van Wezel-Meijler, Gerda [1 ]
机构：
[1] Isala Women & Childrens Hosp, Dept Neonatol, V4-4,POB 10400, NL-8000 GK Zwolle, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht Brain Ctr, Utrecht, Netherlands
[3] Isala Hosp, Dept Radiol, Zwolle, Netherlands
[4] Isala Hosp, Dept Innovat & Sci, Zwolle, Netherlands
[5] Isala Women & Childrens Hosp, Dept Pediat, Zwolle, Netherlands
[6] Univ Med Ctr Utrecht, Dept Neonatol, Utrecht, Netherlands
来源：
EUROPEAN JOURNAL OF RADIOLOGY | 2021年 / 136卷
关键词：
Moderate-late preterm infants; Cranial ultrasound; Magnetic resonance imaging; Brain lesions; Intraventricular hemorrhage; WHITE-MATTER INJURY; PREMATURE-INFANTS; NEONATAL-PERIOD; AGE; DIAGNOSIS; HEMORRHAGE; CHILDREN; BIRTH; BORN; US;
D O I：
10.1016/j.ejrad.2020.109500
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To evaluate the incidence and characteristics of brain lesions in moderate-late preterm (MLPT) infants, born at 32-36 weeks' gestation using cranial ultrasound (cUS) and magnetic resonance imaging (MRI). Methods: Prospective cohort study carried out at Isala Women and Children's Hospital between August 2017 and November 2019. cUS was performed at postnatal day 3-4 (early-cUS), before discharge and repeated at term equivalent age (TEA) in MLPT infants born between 32(+0) and 35(+6) weeks' gestation. At TEA, MRI was also performed. Several brain lesions were assessed e.g. hemorrhages, white matter and deep gray matter injury. Brain maturation was visually evaluated. Lesions were classified as mild or moderate-severe. Incidences and confidence intervals were calculated. Results: 166 MLPT infants were included of whom 127 underwent MRI. One or more mild lesions were present in 119/166 (71.7 %) and moderate-severe lesions in 6/166 (3.6 %) infants on cUS and/or MRI. The most frequent lesions were signs suggestive of white matter injury: inhomogeneous echogenicity in 50/164 infants (30.5 %) at early-cUS, in 12/148 infants (8.1 %) at TEA-cUS and diffuse white matter signal changes (MRI) in 27/127 (23.5 %) infants. Cerebellar hemorrhage (MRI) was observed in 16/127 infants (12.6 %). Delayed maturation (MRI) was seen in 17/117 (13.4 %) infants. Small hemorrhages and punctate white matter lesions were more frequently detected on MRI than on cUS. Conclusions: In MLPT infants mild brain lesions were frequently encountered, especially signs suggestive of white matter injury and small hemorrhages. Moderate-severe lesions were less frequently seen.
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页数：11
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