In and out of the postsynaptic region: signalling proteins on the move

Reversible translocation of signalling proteins to and from their sites of action has emerged as an important theme in Signal transduction. The recent findings of the stimulus-induced translocation of Ca2+-calmodulin dependent protein kinase II (CaMKII) and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor to and from the postsynaptic region are model cases for understanding how the dynamic localization of signalling protein is used to regulate signal transduction.