Platelets in inflammation and atherogenesis

被引：1123
作者：
Gawaz, M [1 ]
Langer, H [1 ]
May, AE [1 ]
机构：
[1] Univ Tubingen, Med Klin 3, D-72076 Tubingen, Germany
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期
关键词：
D O I：
10.1172/JCI27196
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
引用
收藏
页码：3378 / 3384
页数：7
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