Platelets in inflammation and atherogenesis

被引：1123

作者：

Gawaz, M ^{[1
]}

Langer, H ^{[1
]}

May, AE ^{[1
]}

机构：

[1] Univ Tubingen, Med Klin 3, D-72076 Tubingen, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期

关键词：

D O I：

10.1172/JCI27196

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.

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页码：3378 / 3384

页数：7

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