Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population

被引：55

作者：

Bae, Eun Young ^{[1
]}

Lee, Shin Yup ^{[4
]}

Kang, Bong Kyoon

Lee, Eun Jin

Choi, Yi Young

Kang, Hyo-Gyoung

Choi, Jin Eun

Jeon, Hyo-Sung

Lee, Won Kee ^{[2
]}

Kam, Shin ^{[2
]}

Shin, Kyung Min ^{[3
]}

Jin, Guang ^{[5
]}

Yoo, Seung Soo ^{[4
]}

Lee, Jaehee ^{[4
]}

Cha, Seung Ick ^{[4
]}

Kim, Chang Ho ^{[4
]}

Jung, Tae Hoon ^{[4
]}

Park, Jae Yong ^{[4
]}

机构：

[1] Kyungpook Natl Univ, Lung Canc Ctr, Med Ctr, Dept Biochem & Cell Biol,Sch Med, Taegu 702210, South Korea

[2] Kyungpook Natl Univ, Dept Prevent Med, Sch Med, Taegu 702210, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Radiol, Taegu 702210, South Korea

[4] Kyungpook Natl Univ Hosp, Dept Internal Med, Taegu, South Korea

[5] Yanbian Univ, Sch Basic Med, Dept Pharmacol, Yanji, Peoples R China

来源：

RESPIROLOGY | 2012年 / 17卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

genome-wide association study; lung cancer; replication; susceptibility; NICOTINE DEPENDENCE; GENETIC-VARIANTS; RISK; TELOMERASE; 5P15.33; 15Q25; SNPS; ADENOCARCINOMA; POLYMORPHISMS; SMOKING;

D O I：

10.1111/j.1440-1843.2012.02165.x

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background and objective: Genome-wide association studies (GWAS) have identified the three chromosomal regions, 5p15, 6p21 and 15q25, as being associated with lung cancer risk in European populations. This study was performed to confirm these associations in Korean patients with lung cancer. Methods: The genotypes at rs2736100, rs402710, rs401681 and rs31489 at 5p15, rs9295740 at 6p22, which is in extensive linkage disequilibrium with the 6p21 region, as well as rs2036534 and rs6495309 at 15q25, were determined in 1094 patients with lung cancer and 1100 healthy control subjects, who were frequency matched for age and gender. Results: The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32,95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk. The magnitude of the effect was similar to that reported in previous studies, and the association was in the same direction. The effect of SNP in the 5p15 region on the risk of lung cancer was significant only for adenocarcinoma. The two SNP in the 15q25 region were significantly associated with lung cancer risk in ever-smokers and in patients with squamous-cell carcinoma. However, there was no association between the SNP at 6p22 and lung cancer risk. Conclusions: The association between SNP in the 5p15 and 15q25 regions and the risk of lung cancer was confirmed in a Korean population.

引用

页码：699 / 706

页数：8

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