Severe Demyelinating Neuropathy in an Advanced Melanoma Patient Treated with Nivolumab plus Ipilimumab Combined Therapy

被引：4

作者：

Kambayashi, Yumi ^{[1
]}

Fujimura, Taku ^{[1
]}

Kuroda, Hiroshi ^{[2
]}

Otsuka, Atsushi ^{[3
]}

Irie, Hiroyuki ^{[3
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Dept Dermatol, Grad Sch Med, Sendai, Miyagi, Japan

[2] Tohoku Univ, Dept Neurol, Grad Sch Med, Sendai, Miyagi, Japan

[3] Kyoto Univ, Dept Dermatol, Grad Sch Med, Kyoto, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

Demyelinating peripheral neuropathy; Nivolumab plus ipilimumab combined therapy; Advanced melanoma; Immune-related adverse event; High-dose methylprednisolone monotherapy;

D O I：

10.1159/000506976

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors (ICIs) significantly prolong survival in patients with metastatic melanoma but can lead to serious immune-related adverse events. In this report, we described a case of atypical neuropathy caused by nivolumab plus ipilimumab combination therapy before primary tumor resection. In our case, not only demyelinating neuropathy, but also muscle weakness and unilateral facial nerve palsy developed and manifested as severe and diverse symptoms. Moreover, unlike spontaneously developing demyelinating peripheral neuropathy, the present case suggested the therapeutic effects of high-dose methylprednisolone monotherapy for the treatment of ICIs-induced immune-related demyelinating peripheral neuropathy.

引用

页码：474 / 477

页数：4

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