LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis

被引：30
|
作者：
Ma, Junwen [1 ]
Zhang, Lihai [2 ]
Shang, Anquan [3 ]
Song, Hu [4 ]
Huo, Jiege [5 ]
Zhang, Mingjian [6 ]
Jiangg, Liuqin [7 ]
机构：
[1] Ningxia Med Univ, Dept Gastrointestinal Surg, Gen Hosp, Yinchuan, Ningxia, Peoples R China
[2] Jiamusi Univ, Dept Gen Surg & Pediat, Affiliated Hosp 1, Jiamusi, Peoples R China
[3] Sixth Peoples Hosp Yancheng City, Dept Lab Med, Yancheng, Peoples R China
[4] Xuzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China
[5] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Oncol, Nanjing, Peoples R China
[6] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Ctr Clin Res, Sch Med, 100 Haining Rd, Shanghai 200080, Peoples R China
[7] Nanjing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2020年 / 48卷 / 01期
关键词：
Colorectal cancer; LINC02163; MiR-511-3p; AKT3; cell cycle arrest; LONG NONCODING RNA; PROLIFERATION; METASTASIS; DIAGNOSIS; AKT3;
D O I：
10.1080/21691401.2020.1773486
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Long non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with prognosis of CRC patients. Functional experiments demonstrated knockdown of LINC02163 significantly attenuated CRC cells proliferation and metastasis. Mechanism analysis showed miR-511-3p could bind LINC02163 andAKT3, and the expressional level of miR-511-3p negatively correlated with the abundance of LINC02163 andAKT3. Inhibition of LINC02163 suppressed cell proliferation, while transfection of miR-511-3p inhibitor or AKT3 in LINC02163-depletion cells restored cell growth and abolished the cell cycle arrest in G0/G1 phase. Therefore, it was indicated that LINC02163 exerted pro-tumour effect through miR-511-3p/AKT3 axis and was prognostic marker for colorectal cancer.
引用
收藏
页码：961 / 968
页数：8
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