Targeted drug delivery to the retinal pigment epithelium: Untapped therapeutic potential for retinal diseases

被引：15
作者：
Bohley, Marilena [1 ]
Dillinger, Andrea E. [2 ]
Tamm, Ernst R. [2 ]
Goepferich, Achim [1 ]
机构：
[1] Univ Regensburg, Dept Pharmaceut Technol, D-93053 Regensburg, Germany
[2] Univ Regensburg, Dept Human Anat & Embryol, D-93053 Regensburg, Germany
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 09期
关键词：
Retinal pigment epithelium; RPE; Retinal diseases; Retinopathy of prematurity; Diabetic retinopathy; Age-related macular degeneration; Targeted drug delivery; Nanotherapy; DIABETIC-RETINOPATHY; DNA NANOPARTICLES; GENE-EXPRESSION; BRUCHS MEMBRANE; GROWTH-FACTORS; RPE; EYE; SYSTEM; MECHANISMS; RECEPTORS;
D O I：
10.1016/j.drudis.2022.05.024
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopa-thy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the devel-opment of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE.
引用
收藏
页码：2497 / 2509
页数：13
相关论文
共 112 条
  • [51] Kickova E., 2021, PHARMACEUTICS, V14
  • [52] Ocular Drug Delivery to the Retina: Current Innovations and Future Perspectives
    Kim, Hyeong Min
    Woo, Se Joon
    [J]. PHARMACEUTICS, 2021, 13 (01) : 1 - 32
  • [53] Nanoparticle-integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats
    Kim, Hyuncheol
    Csaky, Karl G.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2010, 142 (02) : 286 - 293
  • [54] Investigating the Movement of Intravitreal Human Serum Albumin Nanoparticles in the Vitreous and Retina
    Kim, Hyuncheol
    Robinson, Shaun B.
    Csaky, Karl G.
    [J]. PHARMACEUTICAL RESEARCH, 2009, 26 (02) : 329 - 337
  • [55] Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicity
    Kim, Jeong Hun
    Kim, Jin Hyoung
    Kim, Kyu-Won
    Kim, Myung Hun
    Yu, Young Suk
    [J]. NANOTECHNOLOGY, 2009, 20 (50) : 505101
  • [56] The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation
    Kim, Jin Hyoung
    Kim, Myung Hun
    Jo, Dong Hyun
    Yu, Young Suk
    Lee, Tae Geol
    Kim, Jeong Hun
    [J]. BIOMATERIALS, 2011, 32 (07) : 1865 - 1871
  • [57] Retinopathy of prematurity: a review of risk factors and their clinical significance
    Kim, Sang Jin
    Port, Alexander D.
    Swan, Ryan
    Campbell, J. Peter
    Chan, R. V. Paul
    Chiang, Michael F.
    [J]. SURVEY OF OPHTHALMOLOGY, 2018, 63 (05) : 618 - 637
  • [58] Pigment-epithelium-derived factor - A key coordinator of retinal neuronal and vascular functions.
    King, GL
    Suzuma, K
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (05) : 349 - 351
  • [59] S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA
    Koirala, Adarsha
    Makkia, Rasha S.
    Conley, Shannon M.
    Cooper, Mark J.
    Naash, Muna I.
    [J]. HUMAN MOLECULAR GENETICS, 2013, 22 (08) : 1632 - 1642
  • [60] Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146
    Kolar, G. R.
    Grote, S. M.
    Yosten, G. L. C.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2017, 281 (01) : 25 - 40
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