Targeted drug delivery to the retinal pigment epithelium: Untapped therapeutic potential for retinal diseases

被引：15
作者：
Bohley, Marilena [1 ]
Dillinger, Andrea E. [2 ]
Tamm, Ernst R. [2 ]
Goepferich, Achim [1 ]
机构：
[1] Univ Regensburg, Dept Pharmaceut Technol, D-93053 Regensburg, Germany
[2] Univ Regensburg, Dept Human Anat & Embryol, D-93053 Regensburg, Germany
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 09期
关键词：
Retinal pigment epithelium; RPE; Retinal diseases; Retinopathy of prematurity; Diabetic retinopathy; Age-related macular degeneration; Targeted drug delivery; Nanotherapy; DIABETIC-RETINOPATHY; DNA NANOPARTICLES; GENE-EXPRESSION; BRUCHS MEMBRANE; GROWTH-FACTORS; RPE; EYE; SYSTEM; MECHANISMS; RECEPTORS;
D O I：
10.1016/j.drudis.2022.05.024
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopa-thy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the devel-opment of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE.
引用
收藏
页码：2497 / 2509
页数：13
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