Targeted drug delivery to the retinal pigment epithelium: Untapped therapeutic potential for retinal diseases

被引：15
作者：
Bohley, Marilena [1 ]
Dillinger, Andrea E. [2 ]
Tamm, Ernst R. [2 ]
Goepferich, Achim [1 ]
机构：
[1] Univ Regensburg, Dept Pharmaceut Technol, D-93053 Regensburg, Germany
[2] Univ Regensburg, Dept Human Anat & Embryol, D-93053 Regensburg, Germany
来源：
DRUG DISCOVERY TODAY | 2022年 / 27卷 / 09期
关键词：
Retinal pigment epithelium; RPE; Retinal diseases; Retinopathy of prematurity; Diabetic retinopathy; Age-related macular degeneration; Targeted drug delivery; Nanotherapy; DIABETIC-RETINOPATHY; DNA NANOPARTICLES; GENE-EXPRESSION; BRUCHS MEMBRANE; GROWTH-FACTORS; RPE; EYE; SYSTEM; MECHANISMS; RECEPTORS;
D O I：
10.1016/j.drudis.2022.05.024
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopa-thy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the devel-opment of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE.
引用
收藏
页码：2497 / 2509
页数：13
相关论文
共 112 条
  • [1] Is diabetic retinopathy an inflammatory disease?
    Adamis, AP
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2002, 86 (04) : 363 - 365
  • [2] What is the evidence for systemic effects of intravitreal anti-VEGF agents, and should we be concerned?
    Avery, Robert L.
    [J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2014, 98 : 7 - 10
  • [3] The privileged immunity of immune privileged organs: the case of the eye
    Benhar, Inbal
    London, Anat
    Schwartz, Michal
    [J]. FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [4] Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
    Bhattacharya, Madhushree
    Sarkhel, Sanjay
    Peltoniemi, Jonne
    Broadbridge, Robert
    Tuomainen, Marjo
    Auriola, Seppo
    Urtti, Arto
    [J]. JOURNAL OF CONTROLLED RELEASE, 2017, 251 : 37 - 48
  • [5] Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
    Bhutto, Imran
    Lutty, Gerard
    [J]. MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (04) : 295 - 317
  • [6] Retinal pigment epithelium (RPE) cytoskeleton in vivo and in vitro
    Bonilha, Vera L.
    [J]. EXPERIMENTAL EYE RESEARCH, 2014, 126 : 38 - 45
  • [7] The dynamic nature of Bruch's membrane
    Booij, J. C.
    Baas, D. C.
    Beisekeeva, J.
    Gorgels, T. G. M. F.
    Bergen, A. A. B.
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (01) : 1 - 18
  • [8] The role of the retinal pigment epithelium: topographical variation and ageing changes
    Boulton, M
    Dayhaw-Barker, P
    [J]. EYE, 2001, 15 (3) : 384 - 389
  • [9] Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
    Bourges, JL
    Gautier, SE
    Delie, F
    Bejjani, RA
    Jeanny, JC
    Gurny, R
    BenEzra, D
    Behar-Cohen, FF
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (08) : 3562 - 3569
  • [10] BUNTMILAM AH, 1985, INVEST OPHTH VIS SCI, V26, P1377
12345678910