Synthesis of Fmoc-protected aza-β3-amino acids via reductive amination of glyoxylic acid

被引：15

作者：

Busnel, O ^{[1
]}

Bi, LR ^{[1
]}

Baudy-Floc'h, M ^{[1
]}

机构：

[1] Univ Rennes 1, Inst Chim, CNRS, UMR 6510,Grp Ciblage & Auto Assemblages Fonctionn, F-35042 Rennes, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 41期

关键词：

Aza-beta(3)-amino acid; Fmoc protecting group; peptidomimetics; loading resin; reductive amination;

D O I：

10.1016/j.tetlet.2005.07.160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reductive amination of glyoxylic acid, with a protected Fmoc hydrazine, has been developed as a simple and efficient method for the preparation of Fmoc-aza-beta(3)-amino acid residues (aza-beta(3)-aa). Anchoring on resin of these residues will be described as well as the synthesis of hybrid peptide. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7073 / 7075

页数：3

共 10 条

[1]

BAUDYFLOCH M, 2004, Patent No. 2004111086

[2] Solution synthesis and characterization of aza-β3-peptides (Nα-substituted hydrazino acetic acid oligomers) [J].