Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers

被引：13

作者：

Xia, Yuanliang ^{[1
]}

Yang, Ruohan ^{[2
]}

Zhu, Jianshu ^{[1
]}

Wang, Hengyi ^{[1
]}

Li, Yuehong ^{[1
]}

Fan, Jiawei ^{[3
]}

Fu, Changfeng ^{[1
]}

机构：

[1] First Hosp Jilin Univ, Dept Spine Surg, Changchun, Peoples R China

[2] First Hosp Jilin Univ, Canc Ctr, Changchun, Peoples R China

[3] First Hosp Jilin Univ, Dept Gastroenterol, Changchun, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

nanomaterials; immunotherapy; abscopal effect; metastatic cancer; immune cells; TUMOR-ASSOCIATED MACROPHAGES; BREAST-CANCER; MYELOID CELLS; CPG OLIGODEOXYNUCLEOTIDES; INFLAMMATORY MONOCYTES; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; DENDRITIC CELLS; CO-DELIVERY; TGF-BETA;

D O I：

10.3389/fbioe.2022.890257

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Despite advances in cancer treatment, metastatic cancer is still the main cause of death in cancer patients. At present, the treatment of metastatic cancer is limited to palliative care. The abscopal effect is a rare phenomenon in which shrinkage of metastatic tumors occurs simultaneously with the shrinkage of a tumor receiving localized treatment, such as local radiotherapy or immunotherapy. Immunotherapy shows promise for cancer treatment, but it also leads to consequences such as low responsiveness and immune-related adverse events. As a promising target-based approach, intravenous or intratumoral injection of nanomaterials provides new opportunities for improving cancer immunotherapy. Chemically modified nanomaterials may be able to trigger the abscopal effect by regulating immune cells. This review discusses the use of nanomaterials in killing metastatic tumor cells through the regulation of immune cells and the prospects of such nanomaterials for clinical use.

引用

页数：25

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