Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

被引：12

作者：

Agafonova, Irina G. ^{[1
]}

Moskovkina, Taisiya V. ^{[2
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[2] Far East Fed Univ, Vladivostok 690000, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2015年 / 46卷 / 07期

关键词：

ISATIS-TINCTORIA; COUROUPITA-GUIANENSIS; POLYGONUM-TINCTORIUM; INDOLIC CONSTITUENTS; DERIVATIVES; INDIRUBIN; PRINCIPLE; GLYCOSIDE; PRODUCTS; AUBL;

D O I：

10.1007/s00723-015-0674-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.

引用

页码：781 / 791

页数：11

共 34 条

[1]

Baker W.R., 1995, Patent, Patent No. [US5441955A, 5441955]

[2] Antimicrobial Activity of Tryptanthrins in Escherichia coli [J].

Bandekar, Pooja P. ;

Roopnarine, Keir Alekseii ;

Parekh, Virali J. ;

Mitchell, Thomas R. ;

Novak, Mark J. ;

Sinden, Richard R. .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (09) :3558-3565

[3] THE STRUCTURE AND PROPERTIES OF SOME INDOLIC CONSTITUENTS IN COUROUPITA-GUIANENSIS AUBL [J].

BERGMAN, J ;

LINDSTROM, JO ;

TILSTAM, U .

TETRAHEDRON, 1985, 41 (14) :2879-2881

[4]

BERGMAN J, 1977, TETRAHEDRON LETT, P2625

[5]

Bhattacharjee A., 2004, BIOORGAN MED CHEM, V10, P1979

[6] Modulatory Effects and Action Mechanisms of Tryptanthrin on Murine Myeloid Leukemia Cells [J].

Chan, Hoi-Ling ;

Yip, Hon-Yan ;

Mak, Nai-Ki ;

Leung, Kwok-Nam .

CELLULAR & MOLECULAR IMMUNOLOGY, 2009, 6 (05) :335-342

[7] Quantitative determination of the dual COX-2/5-LOX inhibitor tryptanthrin in Isatis tinctoria by ESI-LC-MS [J].

Danz, H ;

Baumann, D ;

Hamburger, M .

PLANTA MEDICA, 2002, 68 (02) :152-157

[8] Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria [J].

Danz, H ;

Stoyanova, S ;

Wippich, P ;

Brattström, A ;

Hamburger, M .

PLANTA MEDICA, 2001, 67 (05) :411-416

[9]

Friedlander P., 1915, Chem. Ber, V48, P1841

[10]

George V., 1996, Fitoterapia, V67, P553

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