Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

被引：10

作者：

Agafonova, Irina G. ^{[1
]}

Moskovkina, Taisiya V. ^{[2
]}

机构：

[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[2] Far East Fed Univ, Vladivostok 690000, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2015年 / 46卷 / 07期

关键词：

ISATIS-TINCTORIA; COUROUPITA-GUIANENSIS; POLYGONUM-TINCTORIUM; INDOLIC CONSTITUENTS; DERIVATIVES; INDIRUBIN; PRINCIPLE; GLYCOSIDE; PRODUCTS; AUBL;

D O I：

10.1007/s00723-015-0674-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.

引用

页码：781 / 791

页数：11