CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development

被引：13
作者：
Tang, Yiting [1 ,2 ]
Xiong, Kai [1 ,3 ]
Shen, Ming [1 ]
Mu, Yulian [2 ]
Li, Kui [2 ]
Liu, Honglin [1 ]
机构：
[1] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
[2] Chinese Acad Agr Sci, Inst Anim Sci, Dept Gene & Cell Engn, Beijing 100094, Peoples R China
[3] Univ Copenhagen, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg C, Denmark
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2015年 / 401卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
C/EBP beta; IGF1; Liver; Transcription factor; Porcine; FACTOR-I IGF-1; GENE-EXPRESSION; GRANULOSA-CELLS; HUMAN LONGEVITY; MESSENGER-RNA; PHOSPHORYLATION; MUTATIONS; HORMONES; ALPHA; MICE;
D O I：
10.1007/s11010-014-2308-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
IGF1 expression regulation attracts numerous interests because of its important role during mammalian growth and development. Domestic pig can be used as a valuable animal model to investigate human development since they share the high similarity in general physiology and metabolism. In this study, we examined the expression pattern of IGF1 and found it associated with liver C/EBP beta expression pattern in porcine liver during embryonic and postnatal development. Both IGF1 and C/EBP beta expression in liver maintained at low levels before birth and increased after birth. Correspondingly, C/EBP beta demonstrated high binding activity to two sites at IGF1 promoter region in liver after birth. Additionally, IGF1 expression can be activated by C/EBP beta overexpression in porcine primary hepatocytes. These results indicated that C/EBP beta can activate IGF1 expression after birth by binding to IGF1 promoter. Our study may contribute to a better understanding of mammalian development and bring a novel anti-aging pathway in human.
引用
收藏
页码：209 / 218
页数：10
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