Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia

被引：28
|
作者：
Dickerson, Desiree D. [1 ]
Restieaux, Aleisha M. [1 ]
Bilkey, David K. [1 ]
机构：
[1] Univ Otago, Dept Psychol, Dunedin, New Zealand
来源：
SCHIZOPHRENIA RESEARCH | 2012年 / 135卷 / 1-3期
关键词：
Schizophrenia; Synchrony; Clozapine; Animal model; Prefrontal; Hippocampus; PolyI:C; PREFRONTAL CORTEX; ANTIPSYCHOTIC-DRUGS; NEUROLEPTIC-NAIVE; EEG; ANTAGONISM; INFECTION; DEFICITS; RECEPTOR; NEURONS; RATS;
D O I：
10.1016/j.schres.2011.12.016
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The abnormal synchronisation of neural networks may underlie some of the deficits observed in schizophrenia. Abnormal synchronisation can be induced in animal models. We investigated whether acute clozapine treatment might function therapeutically by ameliorating the deficit in theta frequency coherence between the prefrontal cortex and the hippocampus that is induced in rats exposed to maternal immune activation (MIA)-a risk-factor for schizophrenia. Clozapine treatment increased synchrony levels to that of control animals in a dose-dependent manner. Clozapine's effect on synchrony may in part be mediated through increases in local synchrony that occurred in prefrontal cortex but not hippocampus. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：112 / 115
页数：4
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