Mechanism of 6-hydroxydopamine neurotoxicity

被引：0

作者：

Glinka, Y ^{[1
]}

Gassen, M ^{[1
]}

Youdim, MBH ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL, BRUCE RAPPAPORT FAMILY RES INST, DEPT PHARMACOL, FAC MED, IL-31096 HAIFA, ISRAEL

来源：

JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 1997年 / 50期

关键词：

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity. 6-OHDA has two ways of action: it easly forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive towards radical scavengers and iron chelators with the exception of desferrioxamine. We conclude that free radicals are not involved in the interaction between 6-OHDA and the respiratory chain and that the two mechanisms are biochemically independent, although they may act synergistically in vivo.

引用

页码：55 / 66

页数：12

共 41 条

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