Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia and its implication for cranial nerve syndromes

被引:95
作者
Theil, D
Arbusow, V
Derfuss, T
Strupp, M
Pfeiffer, M
Mascolo, A
Brandt, T
机构
[1] Max Planck Inst Neurobiol, Martinsried, Germany
[2] Thermo Hybaid GmbH, Ulm, Germany
[3] Univ Pavia, Dept Neurol, I-27100 Pavia, Italy
[4] LMU, Klinikum Grosshadern, Neurol Forschungshaus, D-81371 Munich, Germany
关键词
D O I
10.1111/j.1750-3639.2001.tb00408.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Herpes simplex virus type 1 (HSV-1) enters sensory neurons and can remain latent there until reactivation. During latency restricted HSV-1 gene expression takes place in the form of latency-associated transcripts (LAT). LAT has been demonstrated to be important not only for latency but also for reactivation, which may cause cranial nerve disorders. Tissue sections of the trigeminal ganglia (TG), geniculate ganglia (GG), and the vestibular ganglia (VG) from seven subjects were examined for the presence of LAT using the in situ hybridization technique. LAT was found on both sides in all TG (100%), on both sides of five subjects (70%) in the GG, and in none of the VG. Using a second more sensitive detection method (RT-PCR), we found LAT in the VG of seven of ten other persons (70%). This is the first study to demonstrate viral latency in the VG, a finding that supports the hypothesis that vestibular neuritis is caused by HSV-1 reactivation. The distribution of LAT in the cranial nerve ganglia indicates that primary infection occurs in the TG and GG and subsequently spreads along the facio-vestibular anastomosis to the VG.
引用
收藏
页码:408 / 413
页数:6
相关论文
共 34 条
[1]   HERPES-SIMPLEX VIRUS IN IDIOPATHIC FACIAL PARALYSIS (BELL PALSY) [J].
ADOUR, KK ;
BELL, DN ;
HILSINGER, RL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 233 (06) :527-530
[2]  
Arbusow V, 1999, ANN NEUROL, V46, P416, DOI 10.1002/1531-8249(199909)46:3<416::AID-ANA20>3.0.CO
[3]  
2-W
[4]   RECOVERY OF HERPES-SIMPLEX VIRUS FROM HUMAN TRIGEMINAL GANGLIONS [J].
BARINGER, JR ;
SWOVELAND, P .
NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (13) :648-650
[5]   HERPESVIRUS HOMINIS - ISOLATION FROM HUMAN TRIGEMINAL GANGLION [J].
BASTIAN, FO ;
TRALKA, TS ;
YEE, CL ;
RABSON, AS .
SCIENCE, 1972, 178 (4058) :306-&
[6]   MORPHOLOGY OF VESTIBULAR NERVE .2. NUMBER OF MYELINATED VESTIBULAR NERVE FIBERS IN MAN AT VARIOUS AGES [J].
BERGSTROM, B .
ACTA OTO-LARYNGOLOGICA, 1973, 76 (2-3) :173-179
[7]   QUANTITY OF LATENCY-ASSOCIATED TRANSCRIPT PRODUCED BY HERPES-SIMPLEX VIRUS IS NOT PREDICTIVE OF THE FREQUENCY OF EXPERIMENTAL RECURRENT GENITAL HERPES [J].
BOURNE, N ;
STANBERRY, LR ;
CONNELLY, BL ;
KURAWADWALA, J ;
STRAUS, SE ;
KRAUSE, PR .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (05) :1084-1087
[8]   2 HERPES-SIMPLEX VIRUS TYPE-1 LATENCY-ACTIVE PROMOTERS DIFFER IN THEIR CONTRIBUTIONS TO LATENCY-ASSOCIATED TRANSCRIPT EXPRESSION DURING LYTIC AND LATENT INFECTIONS [J].
CHEN, XW ;
SCHMIDT, MC ;
GOINS, WF ;
GLORIOSO, JC .
JOURNAL OF VIROLOGY, 1995, 69 (12) :7899-7908
[9]   Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR [J].
Cohrs, RJ ;
Randall, J ;
Smith, J ;
Gilden, DH ;
Dabrowski, C ;
van der Keyl, H ;
Tal-Singer, R .
JOURNAL OF VIROLOGY, 2000, 74 (24) :11464-11471
[10]   INFECTIONS WITH HERPES-SIMPLEX VIRUSES .1. [J].
COREY, L ;
SPEAR, PG .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (11) :686-691