Clinicoimmunological variants of chronic pancreatitis course

Aim. To study relationships between clinical course of chronic pancreatitis (CP) and humoral immunity, in CP patients. Material and methods. Humoral immunity to structural and secretory pancreatic components and some phlogogenic factors of humoral and cellular origin as well as distribution of HLA antigens were studied in 115 CP patients. Results. Two variants of CP course were identified: immunologically dependent and immunologically independent. These variants have typical clinical, laboratory, immunological and immunogenetic differences. Conclusion. Identification of immunologically dependent variant of CP has both fundamental and practical value as it enables more precise prognosis of the disease clinical course and differential approach to its treatment.