DNA methylation as a regulator of intestinal gene expression

被引：11

作者：

Pinho, R. M. ^{[1
]}

Maga, E. A. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA

来源：

BRITISH JOURNAL OF NUTRITION | 2021年 / 126卷 / 11期

关键词：

DNA methylation; Intestines; Nutritional status; Diet; HIGH-FAT DIET; FOLIC-ACID SUPPLEMENTATION; PROTEIN-RESTRICTED DIET; EPIGENETIC REGULATION; PROMOTER METHYLATION; GUT MICROBIOTA; ALTERS METHYLATION; PRENATAL EXPOSURE; MATERNAL OBESITY; IMPRINTED GENES;

D O I：

10.1017/S0007114521000556

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The intestinal tract is the entry gate for nutrients and symbiotic organisms, being in constant contact with external environment. DNA methylation is one of the keys to how environmental conditions, diet and nutritional status included, shape functionality in the gut and systemically. This review aims to summarise findings on the importance of methylation to gut development, differentiation and function. Evidence to date on how external factors such as diet, dietary supplements, nutritional status and microbiota modifications modulate intestinal function through DNA methylation is also presented.

引用

页码：1611 / 1625

页数：15

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