DNA methylation as a regulator of intestinal gene expression

被引：14
作者：
Pinho, R. M. [1 ]
Maga, E. A. [1 ]
机构：
[1] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA
来源：
BRITISH JOURNAL OF NUTRITION | 2021年 / 126卷 / 11期
关键词：
DNA methylation; Intestines; Nutritional status; Diet; HIGH-FAT DIET; FOLIC-ACID SUPPLEMENTATION; PROTEIN-RESTRICTED DIET; EPIGENETIC REGULATION; PROMOTER METHYLATION; GUT MICROBIOTA; ALTERS METHYLATION; PRENATAL EXPOSURE; MATERNAL OBESITY; IMPRINTED GENES;
D O I：
10.1017/S0007114521000556
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The intestinal tract is the entry gate for nutrients and symbiotic organisms, being in constant contact with external environment. DNA methylation is one of the keys to how environmental conditions, diet and nutritional status included, shape functionality in the gut and systemically. This review aims to summarise findings on the importance of methylation to gut development, differentiation and function. Evidence to date on how external factors such as diet, dietary supplements, nutritional status and microbiota modifications modulate intestinal function through DNA methylation is also presented.
引用
收藏
页码：1611 / 1625
页数：15
相关论文
共 50 条
[21]   Integrative analysis of DNA methylation and gene expression in papillary renal cell carcinoma [J].
Singh, Noor Pratap ;
Vinod, P. K. .
MOLECULAR GENETICS AND GENOMICS, 2020, 295 (03) :807-824
[22]   Uncovering the ceRNA network and DNA methylation associated with gene expression in nasopharyngeal carcinoma [J].
Ting Zhang ;
Lu Pei ;
Wen-Li Qiu ;
Yu-xia Wei ;
Bi-yun Liao ;
Feng-lian Yang .
BMC Medical Genomics, 16
[23]   PiiL: visualization of DNA methylation and gene expression data in gene pathways [J].
Moghadam, Behrooz Torabi ;
Zamani, Neda ;
Komorowski, Jan ;
Grabherr, Manfred .
BMC GENOMICS, 2017, 18
[24]   Extended in vitro maturation affects gene expression and DNA methylation in bovine oocytes [J].
Heinzmann, Julia ;
Mattern, Felix ;
Aldag, Patrick ;
Bernal-Ulloa, Sandra Milena ;
Schneider, Tamara ;
Haaf, Thomas ;
Niemann, Heiner .
MOLECULAR HUMAN REPRODUCTION, 2015, 21 (10) :770-782
[25]   Uncovering the ceRNA network and DNA methylation associated with gene expression in nasopharyngeal carcinoma [J].
Zhang, Ting ;
Pei, Lu ;
Qiu, Wen-Li ;
Wei, Yu-xia ;
Liao, Bi-yun ;
Yang, Feng-lian .
BMC MEDICAL GENOMICS, 2023, 16 (01)
[26]   PiiL: visualization of DNA methylation and gene expression data in gene pathways [J].
Behrooz Torabi Moghadam ;
Neda Zamani ;
Jan Komorowski ;
Manfred Grabherr .
BMC Genomics, 18
[27]   Functional impact of sclerostin gene polymorphisms on DNA methylation and gene expression [J].
Del Real, A. ;
Sanudo, C. ;
Garcia-Ibarbia, C. ;
Santurun, A. ;
Zarrabeitia, M. T. ;
Perez-Nunez, M., I ;
Laguna, E. ;
Lopez-Delgado, L. ;
Fernandez, A. F. ;
Fraga, M. F. ;
Riancho, J. A. .
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL, 2019, 11 (04) :98-104
[28]   Response in liver gene expression and DNA methylation to changes in the intestinal microbial profile after in ovo stimulation of chickens [J].
Dunislawska, A. ;
Pietrzak, E. ;
Beldowska, A. ;
Slawinska, A. ;
Siwek, M. .
JOURNAL OF ANIMAL AND FEED SCIENCES, 2023, 32 (02) :152-163
[29]   DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus [J].
Kaaij, Lucas T. J. ;
van de Wetering, Marc ;
Fang, Fang ;
Decato, Benjamin ;
Molaro, Antoine ;
van de Werken, Harmen J. G. ;
van Es, Johan H. ;
Schuijers, Jurian ;
de Wit, Elzo ;
de Laat, Wouter ;
Hannon, Gregory J. ;
Clevers, Hans C. ;
Smith, Andrew D. ;
Ketting, Rene F. .
GENOME BIOLOGY, 2013, 14 (05)
[30]   DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus [J].
Lucas TJ Kaaij ;
Marc van de Wetering ;
Fang Fang ;
Benjamin Decato ;
Antoine Molaro ;
Harmen JG van de Werken ;
Johan H van Es ;
Jurian Schuijers ;
Elzo de Wit ;
Wouter de Laat ;
Gregory J Hannon ;
Hans C Clevers ;
Andrew D Smith ;
René F Ketting .
Genome Biology, 14
12345