Methylxanthines: Potential Therapeutic Agents for Glioblastoma

被引：11

作者：

Perez-Perez, Daniel ^{[1
,2
]}

Reyes-Vidal, Iannel ^{[2
]}

Chavez-Cortez, Elda Georgina ^{[2
]}

Sotelo, Julio ^{[2
]}

Magana-Maldonado, Roxana ^{[2
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Med, PECEM, Mexico City 04510, DF, Mexico

[2] Natl Inst Neurol & Neurosurg, Neuroimmunol & Neurooncol Unit, Mexico City 14269, DF, Mexico

来源：

PHARMACEUTICALS | 2019年 / 12卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

brain tumors; natural alkaloids; drug repositioning; CENTRAL-NERVOUS-SYSTEM; HUMAN PHOSPHODIESTERASE; GLIOMA-CELLS; CHROMOSOMAL LOCALIZATION; GENOMIC ORGANIZATION; SPLICE VARIANTS; THEOBROMA-CACAO; MESSENGER-RNA; CAFFEINE; GENE;

D O I：

10.3390/ph12030130

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Currently, treatment is ineffective and the median overall survival is 20.9 months. The poor prognosis of GBM is a consequence of several altered signaling pathways that favor the proliferation and survival of neoplastic cells. One of these pathways is the deregulation of phosphodiesterases (PDEs). These enzymes participate in the development of GBM and may have value as therapeutic targets to treat GBM. Methylxanthines (MXTs) such as caffeine, theophylline, and theobromine are PDE inhibitors and constitute a promising therapeutic anti-cancer agent against GBM. MTXs also regulate various cell processes such as proliferation, migration, cell death, and differentiation; these processes are related to cancer progression, making MXTs potential therapeutic agents in GBM.

引用

页数：12

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