Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404

被引：39
作者：
Del Arco, I
Navarro, M
Bilbao, A
Ferrer, B
Piomelli, D
De Fonseca, FR
机构：
[1] Fdn Hosp Carlos Haya, Malaga 29010, Spain
[2] Univ Complutense, Dept Psicobiol, Madrid 28224, Spain
[3] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 454卷 / 01期
关键词：
AM404; anandamide; morphine withdrawal;
D O I：
10.1016/S0014-2999(02)02483-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The endogenous cannabinoid, anandamide, has been shown to attenuate naloxone-precipitated opiate withdrawal in rodents. Here we show that the spontaneous, but not the naloxone-precipitated withdrawal syndrome in morphine-dependent mice is attenuated by the inhibitor of carrier-mediated anandamide transport N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (2 and 10 mg/kg, i.p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling. (C) 2002 Elsevier Science B.V All rights reserved.
引用
收藏
页码：103 / 104
页数：2
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