Facile synthesis of novel functionalized 1,3-selenazoles

被引：10

作者：

Kanapickaite, Violeta ^{[1
]}

Martynaitis, Vytas ^{[1
]}

Sackus, Algirdas ^{[1
]}

机构：

[1] Kaunas Univ Technol, Inst Synthet Chem, LT-50254 Kaunas, Lithuania

来源：

ARKIVOC | 2009年

关键词：

2-Amino-1,3-selenazole; selenourea; Hantzsch reaction; heterocycles; RADICAL-CHAIN REDUCTION; SELENAZOLES; SELENOUREA; AGENTS;

D O I：

10.3998/ark.5550190.0010.b24

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of selenourea with diethyl 2,4-dibromo-3-oxoglutarate afforded ethyl 2-(2-amino-5-ethoxycarbonyl-1,3-selenazol-4-yl)-2-bromoethanoate. Treatment of the latter with acylating agents and various nucleophiles gave a series of new 4,5-disubstituted 2-amino-1,3-selenazoles. All compounds were characterized spectroscopically. The crystal structure determination of ethyl 2-(2-amino-5-ethoxycarbonyl-1,3-selenazol-4-yl)-2-bromoethanoate is reported.

引用

页码：268 / 276

页数：9

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