Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and Development

被引：21

作者：

Ansariniya, Hossein ^{[1
]}

Seifati, Seyed Mohammad ^{[2
]}

Zaker, Erfan ^{[3
]}

Zare, Fateme ^{[2
,4
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[2] Shahid Sadoughi Univ Med Sci, Reprod Immunol Res Ctr, Yazd, Iran

[3] Shahid Sadoughi Univ Med Sci, Fac Med, Dept Med Genet, Yazd, Iran

[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran

来源：

BIOMED RESEARCH INTERNATIONAL | 2021年 / 2021卷

关键词：

ACUTE-RESPIRATORY-SYNDROME; NEUTRALIZING ANTIBODIES; CELL RESPONSES; CORONAVIRUS; SPIKE; EXPRESSION; PROTEINS; DISEASES; INNATE;

D O I：

10.1155/2021/8870425

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19) infections are the three epidemiological diseases caused by the Coronaviridae family. Perceiving the immune responses in these infections and the escape of viruses could help us design drugs and vaccines for confronting these infections. This review investigates the innate and adaptive immune responses reported in the infections of the three coronaviruses SARS, MERS, and COVID-19. Moreover, the present study can trigger researchers to design and develop new vaccines and drugs based on immune system responses. In conclusion, due to the need for an effective and efficient immune stimulation against coronavirus, a combination of several strategies seems necessary for developing the vaccine.

引用

页数：11

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