Synaptic plasticity in the subiculum

被引：40

作者：

Behr, Joachim ^{[1
]}

Wozny, Christian ^{[2
]}

Fidzinski, Pawel ^{[1
]}

Schmitz, Dietmar ^{[3
]}

机构：

[1] Charite, Dept Psychiat & Psychotherapy, D-10117 Berlin, Germany

[2] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[3] Charite, Neurosci Res Ctr, D-10117 Berlin, Germany

来源：

PROGRESS IN NEUROBIOLOGY | 2009年 / 89卷 / 04期

关键词：

Subiculum; LTP; LTD; LONG-TERM POTENTIATION; THETA-FREQUENCY STIMULATION; PRESYNAPTIC NMDA RECEPTORS; PAIRED-PULSE FACILITATION; HIPPOCAMPAL AREA CA1; RAT SUBICULUM; PYRAMIDAL NEURONS; ELECTROPHYSIOLOGICAL PROPERTIES; PARAHIPPOCAMPAL REGION; INTRINSIC CONNECTIVITY;

D O I：

10.1016/j.pneurobio.2009.09.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：334 / 342

页数：9

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