The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence
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Chalker, AF
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Chalker, AF
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Ingraham, KA
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Ingraham, KA
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Lunsford, RD
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Lunsford, RD
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Bryant, AP
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Bryant, AP
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Bryant, J
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Bryant, J
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Wallis, NG
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Wallis, NG
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Broskey, JP
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Broskey, JP
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Pearson, SC
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Pearson, SC
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Holmes, DJ
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SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USASmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Holmes, DJ
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]
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[1] SmithKline Beecham Pharmaceut, Antiinfect Res UP1345, Collegeville, PA 19426 USA
Homologues of Escherichia coli bacA. encoding extremely hydrophobic proteins, were identified in the genomes of Staphylococcus aureus and Streptococcus pneumoniae. Allelic replacement mutagenesis demonstrated that the gene is not essential for in vitro growth in either organism, and the mutants showed no significant changes in growth rate or morphology. The Staph. aureus bacA mutant showed slightly reduced virulence in a mouse model of infection and an eightfold increase in bacitracin susceptibility. However, a Strep. pneumoniae bacA mutant was highly attenuated in a mouse model of infection, and demonstrated an increase in susceptibility to bacitracin of up to 160 000-fold. These observations are consistent with the previously proposed role of BacA protein as undecaprenol kinase.