Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases

被引：70

作者：

Aheget, Houssam ^{[1
,2
]}

Mazini, Loubna ^{[3
]}

Martin, Francisco ^{[1
]}

Belqat, Boutaina ^{[2
]}

Antonio Marchal, Juan ^{[4
,5
,6
,7
]}

Benabdellah, Karim ^{[1
]}

机构：

[1] Univ Granada, GENYO Ctr Genom & Oncol Res, Genom Med Dept, Andalusian Reg Govt,Pfizer, Hlth Sci Technol Pk,Av Illustrat 114, Granada 18016, Spain

[2] Univ Abdelmalek Essaadi, Fac Sci, Dept Biol, Tetouan 93000, Morocco

[3] Mohammed VI Polytech Univ, Ctr Biol & Med Sci CIAM, Ben Guerir 43152, Morocco

[4] Biomed Res Inst Ibs GRANADA, Granada 18012, Spain

[5] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada 18016, Spain

[6] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada 18016, Spain

[7] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada 18016, Spain

来源：

CANCERS | 2021年 / 13卷 / 01期

关键词：

exosomes; molecular composition; cancer pathogenesis; diagnostics; therapeutics; CELL-DERIVED EXOSOMES; MESENCHYMAL STEM-CELLS; TUMOR-ASSOCIATED MACROPHAGES; AMYLOID PRECURSOR PROTEIN; ANHYDRASE IX EXPRESSION; MULTIPLE-MYELOMA CELLS; GROWTH-FACTOR RECEPTOR; DOUBLE-STRANDED DNA; EXTRACELLULAR VESICLES; ALPHA-SYNUCLEIN;

D O I：

10.3390/cancers13010084

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary The aim of this review is to provide an overview of the current scientific evidence concerning the role played by exosomes in the pathogenesis, diagnosis and treatment of diseases. The potential use of exosomes as delivery vectors for small-molecule therapeutic agents will be discussed. In addition, a special emphasis will be placed on the involvement of exosomes in oncological diseases, as well as to their potential therapeutic application as liquid biopsy tools mainly in cancer diagnosis. A better understanding of exosome biology could improve the results of clinical interventions using exosomes as therapeutic agents. Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.

引用

页码：1 / 45

页数：45

共 385 条

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