Comparability of antibody response to a booster dose of 7-valent pneumococcal conjugate vaccine in infants primed with either 2 or 3 doses

被引：15

作者：

Rodenburg, Gerwin D. ^{[1
]}

van Gils, Elske J. M. ^{[1
,2
]}

Veenhoven, Reinier H. ^{[2
]}

Jones, Nienke ^{[3
]}

Tcherniaeva, Irina ^{[3
]}

Hak, Eelko ^{[1
,4
,5
]}

van Alphen, Loek ^{[6
]}

Berbers, Guy A. M. ^{[3
]}

Sanders, Elisabeth A. M. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Pediat Immunol & Infect Dis, NL-3584 EA Utrecht, Netherlands

[2] Spaarne Hosp, Dept Pediat, Hoofddorp, Netherlands

[3] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[4] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 EA Utrecht, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[6] Netherlands Vaccine Inst, Bilthoven, Netherlands

来源：

VACCINE | 2010年 / 28卷 / 05期

关键词：

Pneumococcal conjugate vaccine; Immunogenicity; Reduced-dose schedules; STREPTOCOCCUS-PNEUMONIAE; NASOPHARYNGEAL CARRIAGE; LONGITUDINAL HOUSEHOLD; OTITIS-MEDIA; IMMUNOGENICITY; CHILDREN; DISEASE; SAFETY; IMMUNIZATION; PROTECTION;

D O I：

10.1016/j.vaccine.2009.10.151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this cohort study we compared IgG antibody levels between infants immunized with 7-valent CRM197-conjugated pneumococcal vaccine (PCV-7) at 2,4 and 11 months and at 2, 3, 4 and 11 months of age,as measured by double adsorption ELISA. Pre- and post-booster levels following the 2 + 1 - and 3 + 1-dose schedule were comparable for 5 out of 7 serotypes except for serotypes 6B and 19F. The proportion of children reaching post-booster antibody thresholds were comparable except for 6B (>= 1.0 mu g/ml and >= 5.0 mu g/ml) and 19F (>= 5.0 mu g/ml). Surveillance studies are warranted for vaccine impact on 6B and 19F disease cases after reduced-dose PCV-7 schedules. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1391 / 1396

页数：6

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