Co-regulation of mRNA level of UDP glucuronosyltransferase 1A9 and Multi-drug Resistance Protein 2 in Chinese human liver

被引：2
作者：
Zhang, Wei-Xa [1 ]
Chen, Bing [1 ]
Chen, Hao [2 ]
Cai, Qu [2 ]
Cai, Wei-Min [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Pharm, Rui Jin Hosp, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Organ Transplantat Ctr, Shanghai 200025, Peoples R China
[3] Fudan Univ, Sch Pharm, Div Clin Pharm & Management, Shanghai 200433, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2010年 / 411卷 / 1-2期
关键词：
MYCOPHENOLIC-ACID; PRIMARY CULTURES; RAT HEPATOCYTES; DOWN-REGULATION; UP-REGULATION; EXPRESSION; METABOLISM; TRANSPORT; UGT1A9; MRP2;
D O I：
10.1016/j.cca.2009.10.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：119 / 121
页数：3
相关论文
共 28 条
[1]   Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers [J].
Aueviriyavit, Sasitorn ;
Furihata, Tomomi ;
Morimoto, Kaori ;
Kobayashi, Kaoru ;
Chiba, Kan .
DRUG METABOLISM AND PHARMACOKINETICS, 2007, 22 (05) :391-398
[2]   The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants [J].
Bernard, O ;
Guillemette, C .
DRUG METABOLISM AND DISPOSITION, 2004, 32 (08) :775-778
[3]   Substrate specificity of human hepatic Udp-glucuronosyltransferases [J].
Burchell, B ;
Lockley, DJ ;
Staines, A ;
Uesawa, Y ;
Coughtrie, MWH .
PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS, 2005, 400 :46-+
[4]   Improved immunosuppression with combination tacrolimus (FK506) and mycophenolic acid in orthotopic liver transplantation [J].
Cai, TH ;
Esterl, RM ;
Nichols, L ;
Cigarroa, F ;
Speeg, KV ;
Halff, GA .
TRANSPLANTATION PROCEEDINGS, 1998, 30 (04) :1413-1414
[5]   The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability [J].
Chan, LMS ;
Lowes, S ;
Hirst, BH .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 21 (01) :25-51
[6]   DISTRIBUTION OF UDPGLUCURONOSYLTRANSFERASE IN RAT-TISSUE [J].
CHOWDHURY, JR ;
NOVIKOFF, PM ;
CHOWDHURY, NR ;
NOVIKOFF, AB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2990-2994
[7]  
Detry O, 2003, EXPERT OPIN PHARMACO, V4, P1949, DOI 10.1517/eoph.4.11.1949.22357
[8]   Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) [J].
Dietrich, CG ;
de Waart, DR ;
Ottenhoff, R ;
Bootsma, AH ;
van Gennip, AH ;
Elferink, RPJO .
CARCINOGENESIS, 2001, 22 (05) :805-811
[9]  
DUTTON G.J., 1980, GLUCURONIDATION DRUG
[10]   Inducibility of UDP-glucuronosyltransferase 1As by β-naphthoflavone in HepG2 cells [J].
Hanioka, Nobumitsu ;
Obika, Nobuhiko ;
Nishimura, Masuhiro ;
Jinno, Hideto ;
Tanaka-Kagawa, Toshiko ;
Saito, Keita ;
Kiryu, Kimio ;
Naito, Shinsaku ;
Narimatsu, Shizuo .
FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (08) :1251-1260
123