Genetic Abnormalities in Multiple Myeloma: Prognostic and Therapeutic Implications

被引：68
作者：
Cardona-Benavides, Ignacio J. [1 ,2 ]
de Ramon, Cristina [1 ,2 ]
Gutierrez, Norma C. [1 ,2 ,3 ]
机构：
[1] Univ Hosp Salamanca, Dept Hematol, Univ Hosp, Inst Biomed Res Salamanca IBSAL, Salamanca 37007, Spain
[2] Canc Res Ctr IBMCC USAL CSIC, Salamanca 37007, Spain
[3] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
来源：
CELLS | 2021年 / 10卷 / 02期
关键词：
chromosomal translocations; copy number changes; point mutations; multiple myeloma; prognosis; targeted therapy;
D O I：
10.3390/cells10020336
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Some genetic abnormalities of multiple myeloma (MM) detected more than two decades ago remain major prognostic factors. In recent years, the introduction of cutting-edge genomic methodologies has enabled the extensive deciphering of genomic events in MM. Although none of the alterations newly discovered have significantly improved the stratification of the outcome of patients with MM, some of them, point mutations in particular, are promising targets for the development of personalized medicine. This review summarizes the main genetic abnormalities described in MM together with their prognostic impact, and the therapeutic approaches potentially aimed at abrogating the undesirable pathogenic effect of each alteration.
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收藏
页码：1 / 28
页数：26
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共 201 条
  • [1] Implications of MYC Rearrangements in Newly Diagnosed Multiple Myeloma
    Abdallah, Nadine
    Baughn, Linda B.
    Rajkumar, S. Vincent
    Kapoor, Prashant
    Gertz, Morie A.
    Dispenzieri, Angela
    Lacy, Martha Q.
    Hayman, Suzanne R.
    Buadi, Francis K.
    Dingli, David
    Go, Ronald S.
    Hwa, Yi L.
    Fonder, Amie
    Hobbs, Miriam
    Lin, Yi
    Leung, Nelson
    Kourelis, Taxiarchis
    Warsame, Rahma
    Siddiqui, Mustaqeem
    Lust, John
    Kyle, Robert A.
    Ketterling, Rhett
    Bergsagel, Leif
    Greipp, Patricia
    Kumar, Shaji K.
    [J]. CLINICAL CANCER RESEARCH, 2020, 26 (24) : 6581 - 6588
  • [2] Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma
    Affer, M.
    Chesi, M.
    Chen, W. D.
    Keats, J. J.
    Demchenko, Y. N.
    Tamizhmani, K.
    Garbitt, V. M.
    Riggs, D. L.
    Brents, L. A.
    Roschke, A. V.
    Van Wier, S.
    Fonseca, R.
    Bergsagel, P. L.
    Kuehl, W. M.
    [J]. LEUKEMIA, 2014, 28 (08) : 1725 - 1735
  • [3] Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study
    Amorim, Sandy
    Stathis, Anastasios
    Gleeson, Mary
    Iyengar, Sunil
    Magarotto, Valeria
    Leleu, Xavier
    Morschhauser, Franck
    Karlin, Lionel
    Broussais, Florence
    Rezai, Keyvan
    Herait, Patrice
    Kahatt, Carmen
    Lokiec, Francois
    Salles, Gilles
    Facon, Thierry
    Palumbo, Antonio
    Cunningham, David
    Zucca, Emanuele
    Thieblemont, Catherine
    [J]. LANCET HAEMATOLOGY, 2016, 3 (04): : E196 - E204
  • [4] The Impact of Clone Size on the Prognostic Value of Chromosome Aberrations by Fluorescence In Situ Hybridization in Multiple Myeloma
    An, Gang
    Li, Zengjun
    Tai, Yu-Tzu
    Acharya, Chirag
    Li, Qian
    Qin, Xiaoqi
    Yi, Shuhua
    Xu, Yan
    Feng, Xiaoyan
    Li, Chengwen
    Zhao, Jiawei
    Shi, Lihui
    Zang, Meirong
    Deng, Shuhui
    Sui, Weiwei
    Hao, Mu
    Zou, Dehui
    Zhao, Yaozhong
    Qi, Junyuan
    Cheng, Tao
    Ru, Kun
    Wang, Jianxiang
    Anderson, Kenneth C.
    Qiu, Lugui
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (09) : 2148 - 2156
  • [5] Chromosome 1q21 gains confer inferior outcomes in multiple myeloma treated with bortezomib but copy number variation and percentage of plasma cells involved have no additional prognostic value
    An, Gang
    Xu, Yan
    Shi, Lihui
    Zhong, Shizhen
    Deng, Shuhui
    Xie, Zhenqing
    Sui, Weiwei
    Zhan, Fenghuang
    Qiu, Lugui
    [J]. HAEMATOLOGICA, 2014, 99 (02) : 353 - 359
  • [6] A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression
    Annunziata, Christina M.
    Hernandez, Lidia
    Davis, R. Eric
    Zingone, Adriana
    Lamy, Laurence
    Lam, Lloyd T.
    Hurt, Elaine M.
    Shaffer, Arthur L.
    Kuehl, W. Michael
    Staudt, Louis M.
    [J]. BLOOD, 2011, 117 (08) : 2396 - 2404
  • [7] Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project
    Avet-Loiseau, H.
    Durie, B. G. M.
    Cavo, M.
    Attal, M.
    Gutierrez, N.
    Haessler, J.
    Goldschmidt, H.
    Hajek, R.
    Lee, J. H.
    Sezer, O.
    Barlogie, B.
    Crowley, J.
    Fonseca, R.
    Testoni, N.
    Ross, F.
    Rajkumar, S. V.
    Sonneveld, P.
    Lahuerta, J.
    Moreau, P.
    Morgan, G.
    [J]. LEUKEMIA, 2013, 27 (03) : 711 - 717
  • [8] Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone
    Avet-Loiseau, H.
    Soulier, J.
    Fermand, J-P
    Yakoub-Agha, I.
    Attal, M.
    Hulin, C.
    Garderet, L.
    Belhadj, K.
    Dorvaux, V.
    Minvielle, S.
    Moreau, P.
    [J]. LEUKEMIA, 2010, 24 (03) : 623 - 628
  • [9] Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13
    Avet-Loiseau, H
    Daviet, A
    Saunier, S
    Bataille, R
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (04) : 1116 - 1117
  • [10] Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome
    Avet-Loiseau, Herve
    Attal, Michel
    Moreau, Philippe
    Charbonnel, Catherine
    Garban, Frederic
    Hulin, Cyrille
    Leyvraz, Serge
    Michallet, Mauricette
    Yakoub-Agha, Ibrahim
    Garderet, Laurent
    Marit, Gerald
    Michaux, Lucienne
    Voillat, Laurent
    Renaud, Marc
    Grosbois, Bernard
    Guillerm, Gaelle
    Benboubker, Lotfi
    Monconduit, Mathieu
    Thieblemont, Catherine
    Casassus, Philippe
    Caillot, Denis
    Stoppa, Anne-Marie
    Sotto, Jean-Jacques
    Wetterwald, Marc
    Dumontet, Charles
    Fuzibet, Jean-Gabriel
    Azais, Isabelle
    Dorvaux, Veronique
    Zandecki, Marc
    Bataille, Regis
    Minvielle, Stephane
    Harousseau, Jean-Luc
    Facon, Thierry
    Mathiot, Claire
    [J]. BLOOD, 2007, 109 (08) : 3489 - 3495
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