Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivatives and their Schiff's Bases

被引：24

作者：

Chhonker, Y. S. ^{[1
]}

Veenu, B. ^{[1
]}

Hasim, S. R. ^{[1
]}

Kaushik, Niranjan ^{[1
]}

Kumar, Devendra ^{[2
]}

Kumar, Pradeep ^{[3
]}

机构：

[1] IFTM, Coll Pharm, Moradabad, UP, India

[2] CDRI, Pharmacokinet & Metab Div, Lucknow, Uttar Pradesh, India

[3] PES Coll Pharm, Dept Pharmaceut Anal, Bangalore, Karnataka, India

来源：

E-JOURNAL OF CHEMISTRY | 2009年 / 6卷

关键词：

Benzimidazoles; MIC; Antimicrobial activity; Schiff's bases; ANTIPARASITIC AGENTS;

D O I：

10.1155/2009/604203

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some new 2-phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by H-1 NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their in vitro antimicrobial activities against the standard strains: Staphylococcus aureus ATCC - 25923, ATCC - 441 and Bacillus subtilis ATCC-6633 as gram positive, Escherichia coli ATCC - 11775 and Pseudomonas aeruginosa ATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilis and S. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coli and P. Aeruginosa) MIC values between 25 and 200 mg/mL.

引用

页码：S342 / S346

页数：5

共 14 条

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