18F-FDG PET SUVmax Correlates with Osteosarcoma Histologic Response to Neoadjuvant Chemotherapy: Preclinical Evaluation in an Orthotopic Rat Model

被引：9
作者：
Dutour, Aurelie [2 ,4 ]
Decouvelaere, Anne-Valerie [3 ,4 ]
Monteil, Jacques [5 ]
Duclos, Marie-Eve [6 ]
Roualdes, Olivier [6 ]
Rousseau, Raphael [1 ,2 ,4 ,6 ]
Marec-Berard, Perrine [1 ,4 ]
机构：
[1] Inst Hematol Oncol Pediat, F-69373 Lyon 08, France
[2] INSERM, U590, F-69008 Lyon, France
[3] Dept Anatomopathol & Cytol, Lyon, France
[4] Ctr Leon Berard, F-69373 Lyon, France
[5] Ctr Hosp Univ Dupuytren, Nucl Med Serv, Limoges, France
[6] Univ Lyon, Limoges, France
来源：
JOURNAL OF NUCLEAR MEDICINE | 2009年 / 50卷 / 09期
关键词：
osteosarcoma; histologic response; F-18-FDG PET; metabolic response; SUVmax; POSITRON-EMISSION-TOMOGRAPHY; SOFT-TISSUE SARCOMA; CELL LUNG-CANCER; BONE-TUMORS; PROGNOSTIC-FACTORS; BREAST-CANCER; FDG-PET; THERAPY; FOLLOW;
D O I：
10.2967/jnumed.109.062356
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Assessment of osteosarcoma response to neoadjuvant chemotherapy is performed by histopathologic analysis after surgical resection of the primary tumor. The purpose of this study was to evaluate whether F-18-FDG PET could be a noninvasive surrogate to histopathologic analysis and allow for earlier response evaluation to neoadjuvant chemotherapy in osteosarcoma. Methods: Metabolic response to neoadjuvant chemotherapy was assessed in immunocompetent rats with a preestablished orthotopic osteosarcoma using F-18-FDG PET before and after receiving 2 doses of ifosfamide. Comparison was then made by assessing histologic responses on euthanized animals. Results: Maximum standardized uptake value (SUVmax) measured by F-18-FDG PET after 2 doses of chemotherapy was correlated to histologic classification (P < 0.01). An SUVmax less than 15 corresponded to good responders, whereas an SUVmax greater than 15 but less than 20 and an SUVmax greater than 20 corresponded to partial responders or nonresponders, respectively. A 40% decrease in SUVmax between the first and second F-18-FDG PET scans distinguished between partial and good response to chemotherapy. Conclusion: Determination of SUVmax using semiquantitative F-18-FDG PET predicts response to neoadjuvant chemotherapy earlier than does histologic analysis.
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页码：1533 / 1540
页数：8
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