Fungus: A Role in Pathophysiology of Chronic Rhinosinusitis, Disease Modifier, A Treatment Target, or No Role at All?

被引：38

作者：

Fokkens, Wytske J. ^{[1
]}

Ebbens, Fenna

van Drunen, Cornelis M. ^{[1
]}

机构：

[1] Acad Med Ctr, Dept Otorhinolaryngol, Head ENT Res Lab, NL-1100 AZ Amsterdam, Netherlands

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2009年 / 29卷 / 04期

关键词：

Rhinosinusitis; Paranasal sinus diseases; Physiopathology; Diagnosis; Therapy; Fungus; PROTEASE-DEPENDENT ACTIVATION; POLYMERASE-CHAIN-REACTION; TOPICAL AMPHOTERICIN-B; TOLL-LIKE RECEPTORS; EPITHELIAL-CELLS; NASAL POLYPS; CHRONIC SINUSITIS; INNATE IMMUNITY; ANTIFUNGAL TREATMENT; ALLERGIC MUCIN;

D O I：

10.1016/j.iac.2009.07.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Fungal spores, due to their ubiquitous nature, are continuously inhaled and deposited on the airway mucosa. This article focuses on the potential role of fungi in chronic rhinosinusitis (CRS). Five forms of fungal disease affecting the nose and paranasal sinuses have been recognized: (1) acute invasive fungal rhinosinusitis (including rhinocerebral mucormycosis), (2) chronic invasive fungal rhinosinusitis, (3) granulomatous invasive fungal rhinosinusitis, (4) fungal ball (mycetoma), and (5) noninvasive (allergic) fungal rhinosinusitis. There are several potential deficits in the innate and potentially also acquired immunity of CRS patients that might reduce or change their ability to react to fungi. There are not many arguments to suggest a causative role for fungi in CRS with or without nasal polyps. However, due to the intrinsic or induced change in immunity of CRS patients, fungi might have a disease-modifying role.

引用

页码：677 / +

页数：13

共 68 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2] Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GA2LEN study [J].

Bachert, C. ;

Van Bruaene, N. ;

Toskala, E. ;

Zhang, N. ;

Olze, H. ;

Scadding, G. ;

Van Drunen, C. M. ;

Mullol, J. ;

Cardell, L. ;

Gevaert, P. ;

Van Zele, T. ;

Claeys, S. ;

Hallden, C. ;

Kostamo, K. ;

Foerster, U. ;

Kowalski, M. ;

Bieniek, K. ;

Olszewska-Ziaber, A. ;

Nizankowska-Mogilnicka, E. ;

Szczeklik, A. ;

Swierczynska, M. ;

Arcimowicz, M. ;

Lund, V. ;

Fokkens, W. ;

Zuberbier, T. ;

Akdis, C. ;

Canonica, G. ;

Van Cauwenberge, P. ;

Burney, P. ;

Bousquet, J. .

ALLERGY, 2009, 64 (04) :520-533

[3] Identification of human nasal mucous proteins using proteomics [J].

Casado, B ;

Pannell, LK ;

Iadarola, P ;

Baraniuk, JN .

PROTEOMICS, 2005, 5 (11) :2949-2959

[4]

Cavestro Giulia Martina, 2002, Acta Biomed, V73, P71

[5]

CHAKRABARTI A, 2009, LARYNGOSCOP IN PRESS

[6] Human β-defensins and toll-like receptors in the upper airway [J].

Claeys, S ;

de Belder, T ;

Holtappels, G ;

Gevaert, P ;

Verhasselt, B ;

van Cauwenberge, P ;

Bachert, C .

ALLERGY, 2003, 58 (08) :748-753

[7] Prevalence of noninvasive fungal sinusitis in South Australia [J].

Collins, MM ;

Nair, SB ;

Wormald, PJ .

AMERICAN JOURNAL OF RHINOLOGY, 2003, 17 (03) :127-132

[8] Collectins and pulmonary innate immunity [J].

Crouch, E ;

Hartshorn, K ;

Ofek, I .

IMMUNOLOGICAL REVIEWS, 2000, 173 :52-65

[9] DIAGNOSTIC-CRITERIA FOR ALLERGIC FUNGAL SINUSITIS [J].

DESHAZO, RD ;

SWAIN, RE .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (01) :24-35

[10] Expression of TLR2 and TLR4 messenger RNA in the epithelial cells of the nasal airway [J].

Dong, Z ;

Yang, ZQ ;

Wang, CS .

AMERICAN JOURNAL OF RHINOLOGY, 2005, 19 (03) :236-239

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