Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs

被引：77

作者：

Bagowski, Christoph P. ^{[2
]}

You, Ya ^{[3
]}

Scheffler, Heike ^{[3
]}

Vlecken, Danielle H. ^{[2
]}

Schmitza, Daan J. ^{[2
]}

Ott, Ingo ^{[1
]}

机构：

[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Pharmaceut Chem, D-38106 Braunschweig, Germany

[2] Leiden Univ, Inst Biol, Dept Integrat Zool, NL-2333 AL Leiden, Netherlands

[3] Free Univ Berlin, Inst Pharm, D-14195 Berlin, Germany

来源：

DALTON TRANSACTIONS | 2009年 / 48期

关键词：

CELLULAR UPTAKE; METAL-COMPLEXES; PLATINUM COMPLEXES; BINDING PROPERTIES; TUMOR-CELLS; DNA; CYTOTOXICITY; AURANOFIN; ZEBRAFISH; DESIGN;

D O I：

10.1039/b912378d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Gold(I) phosphine complexes exhibit promising properties for anticancer drug development. Here we report on a series of gold(I) phosphine complexes containing a naphthalimide ligand. Strong antiproliferative effects were observed in MCF-7 breast cancer cells as well as in HT-29 colon carcinoma cells. The cellular and nuclear gold levels were increased compared to analogues, in which the naphthalimide ligand was replaced by a chloro ligand. Compound 4a was selected for more detailed biochemical and biological studies, which revealed solvent dependent fluorescence emission, uptake of the compound into the organelles of tumor cells as well as antiangiogenic effects concerning angiogenesis and tumor-induced angiogenesis in vivo. Antiangiogenic properties of 4a were observed in two different zebrafish angiogenesis models, including a tumor-cell induced neovascularization assay.

引用

页码：10799 / 10805

页数：7

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