Mechanisms of vascularization in murine models of primary and metastatic tumor growth

被引：21

作者：

Bugyik, Edina ^{[1
,2
,3
]}

Renyi-Vamos, Ferenc ^{[2
]}

Szabo, Vanessza ^{[1
]}

Dezso, Katalin ^{[1
]}

Ecker, Nora ^{[1
]}

Rokusz, Andras ^{[1
]}

Nagy, Peter ^{[1
]}

Dome, Balazs ^{[2
,4
,5
]}

Paku, Sandor ^{[1
,6
,7
]}

机构：

[1] Semmelweis Univ, Dept Pathol & Expt Canc Res 1, Ulloi Ut 26, H-1085 Budapest, Hungary

[2] Semmelweis Univ, Natl Inst Oncol, Dept Thorac Surg, H-1122 Budapest, Hungary

[3] Hungarian Acad Sci, Postdoctoral Res Programme, H-1051 Budapest, Hungary

[4] Med Univ Vienna, Dept Thorac Surg, A-1090 Vienna, Austria

[5] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, A-1090 Vienna, Austria

[6] Hungarian Acad Sci, Joint Res Org, Tumor Progress Res Grp, Budapest, Hungary

[7] Semmelweis Univ, Ulloi Ut 26, H-1085 Budapest, Hungary

来源：

CHINESE JOURNAL OF CANCER | 2016年 / 35卷

关键词：

Vascularization; Primary tumor; Metastasis; Angiogenesis; EXPERIMENTAL LIVER METASTASES; VESSEL CO-OPTION; INTUSSUSCEPTIVE ANGIOGENESIS; ANTIANGIOGENIC THERAPY; CANCER; BRAIN; VASCULATURE; MELANOMA;

D O I：

10.1186/s40880-016-0083-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.

引用

页数：8

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