Folding and unfolding for binding: large-scale protein dynamics in protein-protein interactions

The role of dynamics in the function of proteins, from enzymes to signalling proteins, is widely recognized. in many cases, the dynamic process is a relatively localized one, involving motion of a limited number of key residues, while in others large-scale domain movements may be involved. These motions all take place within the context of a folded protein; however, there is increasing evidence for the existence of some proteins where a transition between folded and unfolded structures is required for function.