The Effectiveness of Different Eradication Schemes for Pediatric Helicobacter pylori Infection-A Single-Center Comparative Study from Romania

被引：3

作者：

Rosu, Oana-Maria ^{[1
]}

Gimiga, Nicoleta ^{[2
,3
]}

Stefanescu, Gabriela ^{[2
,4
]}

Ioniuc, Ileana ^{[2
,5
]}

Tataranu, Elena ^{[6
,7
]}

Balan, Gheorghe G. ^{[2
,4
]}

Ion, Laura-Mihaela ^{[8
,9
]}

Plesca, Doina Anca ^{[10
,11
]}

Schiopu, Cristina Gabriela ^{[2
]}

Diaconescu, Smaranda ^{[8
]}

机构：

[1] George Emil Palade Univ Med Pharm Sci & Technol T, Doctoral Sch, 38 Gheorghe Marinescu Str, Targu Mures 540139, Romania

[2] Grigore T Popa Univ Med & Pharm, Fac Med, 16 Univ Str, Iasi 700115, Romania

[3] St Mary Emergency Childrens Hosp, Clin Dept Pediat Gastroenterol, 62 Vasile Lupu Str, Iasi 700309, Romania

[4] St Spiridon Emergency Hosp, Gastroenterol & Hepatol Inst, 1-3 Independetei Str, Iasi 700115, Romania

[5] St Mary Emergency Childrens Hosp, Clin Dept Pediat, 62 Vasile Lupu Str, Iasi 700309, Romania

[6] Sf Ioan Cel Nou Emergency Hosp, Clin Dept Pediat, Suceava 720224, Romania

[7] Stefan Cel Mare Univ Suceava, Fac Med & Biol Sci, 13 Univ Str, Suceava 720229, Romania

[8] Titu Maiorescu Univ Med, Fac Med, 67A Gheorghe Petrascu Str, Bucharest 031593, Romania

[9] Regina Maria Hlth Network Bucharest, Ponderas Acad Hosp, Dept Pediat, 85A Nicolae G Caranfil Str, Bucharest 014142, Romania

[10] Carol Davila Univ Med & Pharm, Fac Med, 21 Dionisie Lupu Str, Bucharest 020021, Romania

[11] Dr Victor Gomoiu Clin Childrens Hosp, Clin Dept Pediat, 21 Basarabia Str, Bucharest 22102, Romania

来源：

CHILDREN-BASEL | 2022年 / 9卷 / 09期

关键词：

Helicobacter pylori; children; treatment; eradication; CHILDREN; THERAPY;

D O I：

10.3390/children9091391

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Introduction: In Romania, studies on the pediatric population regarding H. pylori infection or bacterial resistance to antibiotics are limited. Eradication treatment of this infection still raises important problems in medical practice. This study aims to compare the effectiveness of three eradication therapies used against H. pylori infection in the pediatric population. Methods: The prospective study enrolled children aged 6-17 years who were first diagnosed with H. pylori infection. Patients received a randomized treatment either the therapy with clarithromycin (CLR), the therapy with metronidazole (MTZ) or sequential therapy. The effectiveness of the eradication treatment was evaluated after 4-8 weeks from the end of the therapy by testing fecal antigen. Results: 149 patients were enrolled over 18 months. The eradication rates were 49.5% for the treatment scheme with proton pump inhibitor (PPI) + amoxicillin (AMO) + MTZ, 26.7% for PPI + AMO + CLR and 23.8% for sequential therapy. MTZ therapy was superior to CLR therapy, but sequential therapy was not. Side effects were recorded for PPI + AMO + CLR with 39.6%, followed by sequential therapy 37.7%, and only 22.6% for PPI + AMO + MTZ. Conclusions: Therapy with MTZ can achieve a higher eradication rate as a first-line treatment in the case of H. pylori infection. Taking into account that Romania is in an area with increased resistance to CLR, MTZ therapy could be a promising alternative.

引用

页数：9

共 28 条

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