Synthesis and structural studies of (2-oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acids

被引：0
|
作者：
Dolzhenko, AV
Kolotova, NV
Kozminykh, VO
Chui, WK
Heng, PWS
Khrustalev, VN
机构：
[1] Perm State Pharmaceut Acad, Perm 61499, Russia
[2] Natl Univ Singapore, Fac Sci, Dept Pharm, Singapore 117543, Singapore
[3] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia
来源：
HETEROCYCLES | 2004年 / 63卷 / 01期
关键词：
2-aminopyridine; imidazo[1,2-a[pyridine; NMR spectroscopy; X-ray crystallography; tautomerism;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(2-Oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acids (4a-c, 9a-c) were prepared from 2-aminopyridines by acylation with maleic or citraconic anhydrides and followed by Michael addition. Formation of 3-methyl substituted derivatives (9a-c) from citraconic anhydride was found to be regioselective. The molecular conformations of the products in the solution and in the crystal form were discussed based on H-1 NMR spectral and X-Ray data.
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页码：55 / +
页数：9
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