Renewable acrylonitrile production

被引：129

作者：

Karp, Eric M. ^{[1
]}

Eaton, Todd R. ^{[1
]}

Sanchez i Nogue, Violeta ^{[1
]}

Vorotnikov, Vassili ^{[1
]}

Biddy, Mary J. ^{[1
]}

Tan, Eric C. D. ^{[1
]}

Brandner, David G. ^{[1
]}

Cywar, Robin M. ^{[1
]}

Liu, Rongming ^{[2
]}

Manker, Lorenz P. ^{[1
]}

Michener, William E. ^{[1
]}

Gilhespy, Michelle ^{[3
]}

Skoufa, Zinovia ^{[3
]}

Watson, Michael J. ^{[3
]}

Fruchey, O. Stanley ^{[4
]}

Vardon, Derek R. ^{[1
]}

Gill, Ryan T. ^{[2
]}

Bratis, Adam D. ^{[2
]}

Beckham, Gregg T. ^{[1
]}

机构：

[1] Natl Renewable Energy Lab, Natl Bioenergy Ctr, Golden, CO 80401 USA

[2] Univ Colorado, Dept Chem & Biol Engn, Boulder, CO 80309 USA

[3] Johnson Matthey Technol Ctr, Billingham TS23 1LB, Cleveland, England

[4] MATRIC, S Charleston, WV 25303 USA

来源：

SCIENCE | 2017年 / 358卷 / 6368期

关键词：

3-HYDROXYPROPIONIC ACID; ESCHERICHIA-COLI; AMMOXIDATION; GLYCEROL; DEHYDRATION; CONVERSION; CATALYSTS; NITRILES; PATHWAY;

D O I：

10.1126/science.aan1059

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acrylonitrile (ACN) is a petroleum-derived compound used in resins, polymers, acrylics, and carbon fiber. We present a process for renewable ACN production using 3-hydroxypropionic acid (3-HP), which can be produced microbially from sugars. The process achieves ACN molar yields exceeding 90% from ethyl 3-hydroxypropanoate (ethyl 3-HP) via dehydration and nitrilation with ammonia over an inexpensive titanium dioxide solid acid catalyst. We further describe an integrated process modeled at scale that is based on this chemistry and achieves near-quantitative ACN yields (98 +/- 2%) from ethyl acrylate. This endothermic approach eliminates runaway reaction hazards and achieves higher yields than the standard propylene ammoxidation process. Avoidance of hydrogen cyanide as a by-product also improves process safety and mitigates product handling requirements.

引用

页码：1307 / 1310

页数：4

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