DNA methylation and hydroxymethylation in stem cells

被引：39

作者：

Cheng, Ying ^{[1
]}

Xie, Nina ^{[1
,2
]}

Jin, Peng ^{[1
]}

Wang, Tao ^{[3
,4
]}

机构：

[1] Emory Univ, Dept Human Genet, Atlanta, GA 30322 USA

[2] Cent S Univ, Dept Neurol, Xiangya Hosp, Changsha, Hunan, Peoples R China

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2015年 / 33卷 / 04期

关键词：

epigenetics; hydroxymethylation; methylation; stem cells; adult stem cells; SUBVENTRICULAR ZONE ASTROCYTES; 10-11 TRANSLOCATION TET; HEMATOPOIETIC STEM; SELF-RENEWAL; EPIGENETIC REGULATION; ADULT NEUROGENESIS; GENE-EXPRESSION; 5-METHYLCYTOSINE OXIDATION; METHYLTRANSFERASES DNMT3A; SOMATIC-CELLS;

D O I：

10.1002/cbf.3101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, DNA methylation and hydroxymethylation are specific epigenetic mechanisms that can contribute to the regulation of gene expression and cellular functions. DNA methylation is important for the function of embryonic stem cells and adult stem cells (such as haematopoietic stem cells, neural stem cells and germline stem cells), and changes in DNA methylation patterns are essential for successful nuclear reprogramming. In the past several years, the rediscovery of hydroxymethylation and the TET enzymes expanded our insights tremendously and uncovered more dynamic aspects of cytosine methylation regulation. Here, we review the current knowledge and highlight the most recent advances in DNA methylation and hydroxymethylation in embryonic stem cells, induced pluripotent stem cells and several well-studied adult stems cells. Our current understanding of stem cell epigenetics and new advances in the field will undoubtedly stimulate further clinical applications of regenerative medicine in the future. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：161 / 173

页数：13

共 165 条

[1] DNA Demethylation in Pluripotency and Reprogramming: The Role of Tet Proteins and Cell Division [J].

Bagci, Hakan ;

Fisher, Amanda G. .

CELL STEM CELL, 2013, 13 (03) :265-269

[2] Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging [J].

Beerman, Isabel ;

Bock, Christoph ;

Garrison, Brian S. ;

Smith, Zachary D. ;

Gu, Hongcang ;

Meissner, Alexander ;

Rossi, Derrick J. .

CELL STEM CELL, 2013, 12 (04) :413-425

[3] Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells [J].

Blaschke, Kathryn ;

Ebata, Kevin T. ;

Karimi, Mohammad M. ;

Zepeda-Martinez, Jorge A. ;

Goyal, Preeti ;

Mahapatra, Sahasransu ;

Tam, Angela ;

Laird, Diana J. ;

Hirst, Martin ;

Rao, Anjana ;

Lorincz, Matthew C. ;

Ramalho-Santos, Miguel .

NATURE, 2013, 500 (7461) :222-+

[4] Male germline stem cells: From mice to men [J].

Brinster, Ralph L. .

SCIENCE, 2007, 316 (5823) :404-405

[5] DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction [J].

Broeske, Ann-Marie ;

Vockentanz, Lena ;

Kharazi, Shabnam ;

Huska, Matthew R. ;

Mancini, Elena ;

Scheller, Marina ;

Kuhl, Christiane ;

Enns, Andreas ;

Prinz, Marco ;

Jaenisch, Rudolf ;

Nerlov, Claus ;

Leutz, Achim ;

Andrade-Navarro, Miguel A. ;

Jacobsen, Sten Eirik W. ;

Rosenbauer, Frank .

NATURE GENETICS, 2009, 41 (11) :1207-1215

[6] Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver [J].

Brunner, Alayne L. ;

Johnson, David S. ;

Kim, Si Wan ;

Valouev, Anton ;

Reddy, Timothy E. ;

Neff, Norma F. ;

Anton, Elizabeth ;

Medina, Catherine ;

Nguyen, Loan ;

Chiao, Eric ;

Oyolu, Chuba B. ;

Schroth, Gary P. ;

Absher, Devin M. ;

Baker, Julie C. ;

Myers, Richard M. .

GENOME RESEARCH, 2009, 19 (06) :1044-1056

[7] Plzf is required in adult male germ cells for stem cell self-renewal [J].

Buaas, FW ;

Kirsh, AL ;

Sharma, M ;

McLean, DJ ;

Morris, JL ;

Griswold, MD ;

de Rooij, DG ;

Braun, RE .

NATURE GENETICS, 2004, 36 (06) :647-652

[8] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[9] Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells [J].

Challen, Grant A. ;

Sun, Deqiang ;

Mayle, Allison ;

Jeong, Mira ;

Luo, Min ;

Rodriguez, Benjamin ;

Mallaney, Cates ;

Celik, Hamza ;

Yang, Liubin ;

Xia, Zheng ;

Cullen, Sean ;

Berg, Jonathan ;

Zheng, Yayun ;

Darlington, Gretchen J. ;

Li, Wei ;

Goodell, Margaret A. .

CELL STEM CELL, 2014, 15 (03) :350-364

[10] Dnmt3a is essential for hematopoietic stem cell differentiation [J].

Challen, Grant A. ;

Sun, Deqiang ;

Jeong, Mira ;

Luo, Min ;

Jelinek, Jaroslav ;

Berg, Jonathan S. ;

Bock, Christoph ;

Vasanthakumar, Aparna ;

Gu, Hongcang ;

Xi, Yuanxin ;

Liang, Shoudan ;

Lu, Yue ;

Darlington, Gretchen J. ;

Meissner, Alexander ;

Issa, Jean-Pierre J. ;

Godley, Lucy A. ;

Li, Wei ;

Goodell, Margaret A. .

NATURE GENETICS, 2012, 44 (01) :23-U43

← 1 2 3 4 5 6 7 8 9 10 →