The Functional Promoter Polymorphism of the Coagulation Factor XII Gene is not Associated With Peripheral Arterial Disease

被引：0

作者：

Yazdani-Biuki, Babak ^{[2
]}

Krippl, Peter

Brickmann, Kerstin ^{[2
]}

Fuerst, Florentine ^{[2
]}

Langsenlehner, Uwe ^{[5
]}

Paulweber, Bernhard ^{[6
]}

Pilger, Ernst ^{[3
]}

Wascher, Thomas C. ^{[4
]}

Brezinschek, Hans-Peter ^{[2
]}

Renner, Wilfried ^{[1
]}

机构：

[1] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

[2] Med Univ Graz, Div Rheumatol, A-8036 Graz, Austria

[3] Med Univ Graz, Div Angiol, A-8036 Graz, Austria

[4] Med Univ Graz, Metab & Vasc Biol Unit, Dept Med, A-8036 Graz, Austria

[5] Steiermaerk Gebietskrankenkasse, Internal Outpatient Dept, Graz, Austria

[6] Landeskrankenanstalten Salzburg, Dept Internal Med 1, Salzburg, Austria

来源：

ANGIOLOGY | 2010年 / 61卷 / 02期

关键词：

peripheral arterial disease; coagulation factor XII; genetics; polymorphism; CORONARY-HEART-DISEASE; RISK-FACTOR; 5'-UNTRANSLATED REGION; ACTIVATED FXII; FACTOR-VII; F12; GENE; HOMOZYGOSITY; COMMON; SURVIVORS; 46C;

D O I：

10.1177/0003319709337305

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral arterial disease (PAD), we performed a case-control study including 668 patients with PAD and 762 controls participants without cardiovascular disease. F12 genotype frequencies were not significantly different between patients with PAD and control participants. After adjustment for classical risk factors, the odds ratio of carriers of a F12-4T allele for PAD was 1.06 (95% confidence interval 0.86-1.32). F12 genotypes were associated with a modest increase of the mean-activated partial thromboplastin time but not with PAD stage or severity. We conclude that the functional F12-4C>T polymorphism is not associated with PAD.

引用

页码：211 / 215

页数：5

共 28 条

[21]

Sanchez L A, 1998, Vasc Med, V3, P291

[22] Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for ischemic stroke in the Spanish population [J].

Santamaría, A ;

Mateo, J ;

Tirado, I ;

Oliver, A ;

Belvís, R ;

Martí-Fábregas, J ;

Felices, R ;

Soria, JM ;

Souto, JC ;

Fontcuberta, J .

STROKE, 2004, 35 (08) :1795-1799

[23] Mendelian randomization: prospects, potentials, and limitations [J].

Smith, GD ;

Ebrahim, S .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (01) :30-42

[24] A quantitative-trait locus in the human factor XII gene influences both plasma factor XII levels and susceptibility to thrombotic disease [J].

Soria, JM ;

Almasy, L ;

Souto, JC ;

Bacq, D ;

Buil, A ;

Faure, A ;

Martínez-Marchán, E ;

Mateo, J ;

Borrell, M ;

Stone, W ;

Lathrop, M ;

Fontcuberta, J ;

Blangero, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (03) :567-574

[25] STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF FACTOR-XII [J].

TANS, G ;

ROSING, J .

SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1987, 13 (01) :1-14

[26] Association after linkage analysis indicates that homozygosity for the 46C→T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis [J].

Tirado, I ;

Soria, JM ;

Mateo, J ;

Oliver, A ;

Souto, JC ;

Santamaria, A ;

Felice, R ;

Borrell, M ;

Fontcuberta, J .

THROMBOSIS AND HAEMOSTASIS, 2004, 91 (05) :899-904

[27] Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men [J].

Zito, F ;

Drummond, F ;

Bujac, SR ;

Esnouf, MP ;

Morrissey, JH ;

Humphries, SE ;

Miller, GJ .

CIRCULATION, 2000, 102 (17) :2058-2062

[28] Association of the factor XII 46C > T polymorphism with risk of coronary heart disease (CHD) in the WOSCOPS study [J].

Zito, F ;

Lowe, GDO ;

Rumley, A ;

McMahon, AD ;

Humphries, SE .

ATHEROSCLEROSIS, 2002, 165 (01) :153-158

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