A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

被引：112

作者：

Ahmad, Awais ^{[1
]}

Mubarak, N. M. ^{[2
]}

Jannat, Fakiha Tul ^{[3
]}

Ashfaq, Tayyaba ^{[3
]}

Santulli, Carlo ^{[4
]}

Rizwan, Muhammad ^{[5
]}

Najda, Agnieszka ^{[6
]}

Bin-Jumah, May ^{[7
]}

Abdel-Daim, Mohamed M. ^{[8
,9
]}

Hussain, Shahid ^{[10
]}

Ali, Shafaqat ^{[5
,11
]}

机构：

[1] Univ Lahore, Dept Chem, Lahore 54590, Pakistan

[2] Curtin Univ, Fac Engn & Sci, Dept Chem Engn, Sarawak 98009, Malaysia

[3] Govt Coll Univ, Dept Chem, Faisalabad 38000, Pakistan

[4] Univ Camerino, Sch Sci & Technol, Geol Div SST, Via Gentile III da Varano, I-62032 Camerino, Italy

[5] Govt Coll Univ, Dept Environm Sci & Engn, Faisalabad 38000, Pakistan

[6] Univ Life Sci Lublin, Dept Vegetable Crops & Med Plants, Lab Qual Vegetables & Med Plants, 15 Akad St, PL-20950 Lublin, Poland

[7] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Biol Dept, Riyadh 11564, Saudi Arabia

[8] King Saud Univ, Sci Coll, Dept Zool, Riyadh 11451, Saudi Arabia

[9] Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt

[10] Jiangsu Univ, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[11] China Med Univ CMU, Dept Biol Sci & Technol, Taichung 40402, Taiwan

来源：

PROCESSES | 2021年 / 9卷 / 01期

关键词：

sodium alginate; natural polymer; biomedical delivery; gene delivery; biomedical application;

D O I：

10.3390/pr9010137

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the derivative of alginic acid which comprises 1,4-beta-d-mannuronic (M) and alpha-l-guluronic (G) acids and has the chemical formula (NaC6H7O6). It shows water-soluble, non-toxic, biocompatible, biodegradable, and non-immunogenic properties. It had been used for various biomedical applications, among which the most promising are drug delivery, gene delivery, wound dressing, and wound healing. For different biomedical applications, it is used in different forms with the help of new techniques. That is the reason it had been blended with different polymers. In this review article, we present a comprehensive overview of the combinations of sodium alginate with natural and synthetic polymers and their biomedical applications involving delivery systems. All the scientific/technical issues have been addressed, and we have highlighted the recent advancements.

引用

页码：1 / 27

页数：27

共 174 条

[1] Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles:: effects of acyl chain length [J].