Novel Lipid-Oligonucleotide Conjugates Containing Long-Chain Sulfonyl Phosphoramidate Groups: Synthesis and Biological Properties

被引：10

作者：

Derzhalova, Alina ^{[1
,2
]}

Markov, Oleg ^{[2
]}

Fokina, Alesya ^{[1
,3
]}

Shiohama, Yasuo ^{[4
]}

Zatsepin, Timofei ^{[5
,6
]}

Fujii, Masayuki ^{[7
]}

Zenkova, Marina ^{[2
]}

Stetsenko, Dmitry ^{[1
,3
]}

机构：

[1] Novosibirsk State Univ, Dept Phys, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

[3] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 63090, Russia

[4] Univ Ryukyus, Trop Biosphere Res Ctr, Nishihara, Okinawa 9030213, Japan

[5] Skolkovo Inst Sci & Technol, Innovat Ctr Skolkovo, Moscow 121205, Russia

[6] Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia

[7] Kindai Univ, Dept Biol & Environm Chem, Iizuka, Fukuoka 8208555, Japan

来源：

APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 03期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

therapeutic nucleic acid; drug delivery; nanoparticles; cytotoxicity; macrophages; cellular uptake; small interfering RNA; multiple sclerosis; repulsive guidance molecule a; CELLULAR UPTAKE; ANTISENSE OLIGONUCLEOTIDES; RNA; DERIVATIVES; INHIBITION; EFFICIENCY; DELIVERY; THERAPY; SIRNAS; GENE;

D O I：

10.3390/app11031174

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New lipid conjugates of DNA and RNA incorporating one to four [(4-dodecylphenyl)sulfonyl]phosphoramidate or (hexadecylsulfonyl)phosphoramidate groups at internucleotidic positions near the 3 ' or 5 '-end were synthesized and characterized. Low cytotoxicity of the conjugates and their ability to be taken up into cells without transfection agents were demonstrated. Lipid-conjugated siRNAs targeting repulsive guidance molecules a (RGMa) have shown a comparable gene silencing activity in PK-59 cells to unmodified control siRNA when delivered into the cells via Lipofectamine mediated transfection.

引用

页码：1 / 15

页数：15

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