Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

被引：6

作者：

Gratuze, Maud ^{[1
]}

Holtzman, David M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, Hope Ctr Neurol Disorders,Dept Neurol, St Louis, MO 63110 USA

来源：

NEURON | 2021年 / 109卷 / 05期

关键词：

D O I：

10.1016/j.neuron.2021.02.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

引用

页码：741 / 743

页数：3

共 39 条

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