Circular RNAs: Identification, biogenesis and function

被引：476

作者：

Ebbesen, Karoline K. ^{[1
]}

Kjems, Jorgen ^{[1
]}

Hansen, Thomas B. ^{[1
]}

机构：

[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Dept Mol Biol & Genet MBG, Aarhus, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 01期

关键词：

Circular RNA; circRNA; GENE; TRANSCRIPTS; EFFICIENT; REVEALS;

D O I：

10.1016/j.bbagrm.2015.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circular RNAs are a novel class of non-coding RNA characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. Circular RNAs are widely expressed in a tissue and developmental-stage specific pattern and a subset displays conservation across species. Functional circRNAs have been shown to act as cytoplasmic microRNA sponges and RNA-binding protein sequestering agents as well as nuclear transcriptional regulators, illustrating the relevance of circular RNAs as participants in the regulatory networks governing gene expression. Here, we review the features that characterize circular RNAs, discuss putative circular RNA biogenesis pathways as well as review the uncovered functions of circular RNAs. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：163 / 168

页数：6

共 41 条

[1] circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[2] Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk [J].

Burd, Christin E. ;

Jeck, William R. ;

Liu, Yan ;

Sanoff, Hanna K. ;

Wang, Zefeng ;

Sharpless, Norman E. .

PLOS GENETICS, 2010, 6 (12) :1-15

[3] CIRCULAR TRANSCRIPTS OF THE TESTIS-DETERMINING GENE SRY IN ADULT-MOUSE TESTIS [J].

CAPEL, B ;

SWAIN, A ;

NICOLIS, S ;

HACKER, A ;

WALTER, M ;

KOOPMAN, P ;

GOODFELLOW, P ;

LOVELLBADGE, R .

CELL, 1993, 73 (05) :1019-1030

[4] MISSPLICING YIELDS CIRCULAR RNA MOLECULES [J].

COCQUERELLE, C ;

MASCREZ, B ;

HETUIN, D ;

BAILLEUL, B .

FASEB JOURNAL, 1993, 7 (01) :155-160

[5] The RNA Binding Protein Quaking Regulates Formation of circRNAs [J].

Conn, Simon J. ;

Pillman, Katherine A. ;

Toubia, John ;

Conn, Vanessa M. ;

Salmanidis, Marika ;

Phillips, Caroline A. ;

Roslan, Suraya ;

Schreiber, Andreas W. ;

Gregory, Philip A. ;

Goodall, Gregory J. .

CELL, 2015, 160 (06) :1125-1134

[6] CIRI: an efficient and unbiased algorithm for de novo circular RNA identification [J].

Gao, Yuan ;

Wang, Jinfeng ;

Zhao, Fangqing .

GENOME BIOLOGY, 2015, 16

[7] circBase: a database for circular RNAs [J].

Glazar, Petar ;

Papavasileiou, Panagiotis ;

Rajewsky, Nikolaus .

RNA, 2014, 20 (11) :1666-1670

[8] Expanded identification and characterization of mammalian circular RNAs [J].

Guo, Junjie U. ;

Agarwal, Vikram ;

Guo, Huili ;

Bartel, David P. .

GENOME BIOLOGY, 2014, 15 (07)

[9] Modular regulatory principles of large non-coding RNAs [J].

Guttman, Mitchell ;

Rinn, John L. .

NATURE, 2012, 482 (7385) :339-346

[10] Circular RNA and miR-7 in Cancer [J].

Hansen, Thomas B. ;

Kjems, Jorgen ;

Damgaard, Christian K. .

CANCER RESEARCH, 2013, 73 (18) :5609-5612

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