Is Wnt signalling the final common pathway leading to bone formation?

被引：103

作者：

Milat, Frances ^{[1
,2
,3
]}

Ng, Kong Wah ^{[2
,3
]}

机构：

[1] Prince Henrys Inst, Clayton, Vic 3168, Australia

[2] St Vincents Inst, Fitzroy, Vic 3065, Australia

[3] St Vincents Hlth, Dept Endocrinol & Diabet, Fitzroy, Vic 3065, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 310卷 / 1-2期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Bone formation; Wnt; LRP; Osteoblasts; PTH; BMPs; FRIZZLED-RELATED PROTEIN-1; RECEPTOR-RELATED PROTEIN-5; PARATHYROID-HORMONE; BETA-CATENIN; OSTEOBLAST DIFFERENTIATION; FUNCTIONAL INTERACTION; MICROARRAY ANALYSIS; NEGATIVE REGULATOR; MISSENSE MUTATIONS; HEAD INDUCTION;

D O I：

10.1016/j.mce.2009.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the discovery of the link between mutations in the LRP5 gene and human bone mass, considerable progress has been made in our understanding of Wnt signalling and bone formation. The connection between canonical Writ signalling and bone formation is convincing, and there is evidence of interaction between the Wnt signalling pathway and key growth factors, transcriptional factors and systemic hormones. More recently, the role of the non-canonical pathway in bone metabolism has also started to be explored as well as potential bone-gut interactions. This review focuses on the role of the Writ pathway in osteoblast differentiation as well as the interplay between Wnt signalling and other pathways involved in bone formation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 62

页数：11

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