Multicomponent and One-pot Syntheses of Quinoxalines

被引：68

作者：

Biesen, Lukas ^{[1
]}

Mueller, Thomas J. J. ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Organ Chem & Makromol Chem, Univ Str 1, D-40225 Dusseldorf, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 04期

关键词：

Heterocycles; Multicomponent reactions; One-pot processes; Quinoxalines; TANDEM OXIDATION PROCESSES; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLIC CHEMISTRY; 3-ETHYNYL QUINOXALINES; 3-COMPONENT SYNTHESIS; GREEN SYNTHESIS; SOLAR-CELLS; EFFICIENT; DERIVATIVES; NANOPARTICLES;

D O I：

10.1002/adsc.202001219

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Quinoxalines represent bicyclic nitrogen-containing heterocycles with a wide array of applications. They exhibit a multitude of biological activities relevant in medicinal chemistry as well as a plethora of luminescence properties. Quinoxaline syntheses exploit the whole raft of multicomponent syntheses from domino to sequential or consecutive reactions, harvesting well-known synthetic concepts and reactions, such as Ugi-reactions, but also leading to the development of novel reactions and sequences. Diversity-oriented synthesis and transition metal catalyzed multicomponent reactions open efficient pathways to quinoxalines and quinoxaline-containing moieties in a one-pot fashion. This review outlines the underlying reaction-based principles of multicomponent syntheses of quinoxalines and summarizes recent developments quinoxaline-directed MCRs, illustrating their scopes.

引用

页码：980 / 1006

页数：27

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