Ancient genomic changes associated with domestication of the horse

被引：139

作者：

Librado, Pablo ^{[1
]}

Gamba, Cristina ^{[1
]}

Gaunitz, Charleen ^{[1
]}

Sarkissian, Clio Der ^{[1
]}

Pruvost, Melanie ^{[2
]}

Albrechtsen, Anders ^{[3
]}

Fages, Antoine ^{[1
,4
]}

Khan, Naveed ^{[1
,5
]}

Schubert, Mikkel ^{[1
]}

Jagannathan, Vidhya ^{[6
]}

Serres-Armero, Aitor ^{[7
,8
]}

Kuderna, Lukas F. K. ^{[7
,8
]}

Povolotskaya, Inna S. ^{[7
,8
]}

Seguin-Orlando, Andaine ^{[1
,9
]}

Lepetz, Sebastien ^{[10
]}

Neuditschko, Markus ^{[11
]}

Theves, Catherine ^{[4
]}

Alquraishi, Saleh ^{[12
]}

Alfarhan, Ahmed H. ^{[12
]}

Al-Rasheid, Khaled ^{[12
]}

Rieder, Stefan ^{[11
]}

Samashev, Zainolla ^{[13
]}

Francfort, Henri-Paul ^{[14
]}

Benecke, Norbert ^{[15
]}

Hofreiter, Michael ^{[16
]}

Ludwig, Arne ^{[17
]}

Keyser, Christine ^{[4
,18
]}

Marques-Bonet, Tomas ^{[7
,8
,19
]}

Ludes, Bertrand ^{[4
,20
]}

Crubezy, Eric ^{[4
]}

Leeb, Tosso ^{[6
]}

Willerslev, Eske ^{[1
]}

Orlando, Ludovic ^{[1
,4
]}

机构：

[1] Nat Hist Museum Denmark, Ctr GeoGenet, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark

[2] Univ Paris Diderot, CNRS, UMR 7592, Inst Jacques Monod, F-75205 Paris 13, France

[3] Univ Copenhagen, Dept Biol, Bioinformat Ctr, DK-2200 Copenhagen N, Denmark

[4] Univ Paul Sabatier, Univ Toulouse, Lab Anthropobiol Mol & Imagerie Synth, CNRS,UMR 5288, F-31000 Toulouse, France

[5] Abdul Wali Khan Univ, Dept Biotechnol, Mardan, Pakistan

[6] Univ Bern, Inst Genet, CH-3001 Bern, Switzerland

[7] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Inst Evolutionary Biol CSIC UPF, Barcelona 08003, Spain

[8] Barcelona Inst Sci & Technol, Ctr Genom Regulat CNAG CRG, Baldiri & Reixac 4, Barcelona 08028, Spain

[9] Natl High Throughput DNA Sequencing Ctr, Copenhagen, Denmark

[10] Sorbonne Univ, CNRS, Museum Natl Hist Nat, Archeozool Archeobot Soc Prat & Environm UMR 7209, 55 Rue Buffon, F-75005 Paris, France

[11] Swiss Natl Stud Farm, Agroscope, CH-1580 Avenches, Switzerland

[12] King Saud Univ, Coll Sci, Zool Dept, Riyadh 11451, Saudi Arabia

[13] Branch Inst Archaeol Margulan, Republ Ave 24-405, Astana 010000, Kazakhstan

[14] CNRS, UMR Archeol & Sci Antiqu, Archeol Asie Cent, Maison Rene Ginouves, 21 Allee Univ, F-92023 Nanterre, France

[15] German Archaeol Inst, Dept Nat Sci, D-14195 Berlin, Germany

[16] Univ Potsdam, Fac Math & Nat Sci, Inst Biochem & Biol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany

[17] Leibniz Inst Zoo & Wildlife Res, Dept Evolutionary Genet, D-10315 Berlin, Germany

[18] Univ Strasbourg, Inst Med Legale, Strasbourg, France

[19] Catalan Inst Res & Adv Studies ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

[20] Univ Paris 05, Inst Med Legal, Paris, France

来源：

SCIENCE | 2017年 / 356卷 / 6336期

基金：

新加坡国家研究基金会; 欧洲研究理事会;

关键词：

COMPLETE MITOCHONDRIAL GENOME; WIDE SNP-ASSOCIATION; COAT COLOR; MISSENSE MUTATION; POPULATION-GENETICS; PHYLOGENETIC ANALYSIS; SPOTTING PATTERN; READ ALIGNMENT; DNA EXTRACTION; RECEPTOR GENE;

D O I：

10.1126/science.aam5298

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between similar to 4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.

引用

页码：442 / 445

页数：4

共 163 条

[1] Mitochondrial genomes from modern horses reveal the major haplogroups that underwent domestication [J].

Achilli, Alessandro ;

Olivieri, Anna ;

Soares, Pedro ;

Lancioni, Hovirag ;

Kashani, Baharak Hooshiar ;

Perego, Ugo A. ;

Nergadze, Solomon G. ;

Carossa, Valeria ;

Santagostino, Marco ;

Capomaccio, Stefano ;

Felicetti, Michela ;

Al-Achkar, Walid ;

Penedo, M. Cecilia T. ;

Verini-Supplizi, Andrea ;

Houshmand, Massoud ;

Woodward, Scott R. ;

Semino, Ornella ;

Silvestrelli, Maurizio ;

Giulotto, Elena ;

Pereira, Luisa ;

Bandelt, Hans-Juergen ;

Torroni, Antonio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (07) :2449-2454

[2] INFECTION OF COLONIZED CAT FLEAS, CTENOCEPHALIDES-FELIS (BOUCHE), WITH A RICKETTSIA-LIKE MICROORGANISM [J].

ADAMS, JR ;

SCHMIDTMANN, ET ;

AZAD, AF .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1990, 43 (04) :400-409

[3] Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia [J].

Aleman, M ;

Riehl, J ;

Aldridge, BM ;

Lecouteur, RA ;

Stott, JL ;

Pessah, IN .

MUSCLE & NERVE, 2004, 30 (03) :356-365

[4] Personalized copy number and segmental duplication maps using next-generation sequencing [J].

Alkan, Can ;

Kidd, Jeffrey M. ;

Marques-Bonet, Tomas ;

Aksay, Gozde ;

Antonacci, Francesca ;

Hormozdiari, Fereydoun ;

Kitzman, Jacob O. ;

Baker, Carl ;

Malig, Maika ;

Mutlu, Onur ;

Sahinalp, S. Cenk ;

Gibbs, Richard A. ;

Eichler, Evan E. .

NATURE GENETICS, 2009, 41 (10) :1061-U29

[5] Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice [J].

Andersson, Lisa S. ;

Larhammar, Martin ;

Memic, Fatima ;

Wootz, Hanna ;

Schwochow, Doreen ;

Rubin, Carl-Johan ;

Patra, Kalicharan ;

Arnason, Thorvaldur ;

Wellbring, Lisbeth ;

Hjalm, Goran ;

Imsland, Freyja ;

Petersen, Jessica L. ;

McCue, Molly E. ;

Mickelson, James R. ;

Cothran, Gus ;

Ahituv, Nadav ;

Roepstorff, Lars ;

Mikko, Sofia ;

Vallstedt, Anna ;

Lindgren, Gabriella ;

Andersson, Leif ;

Kullander, Klas .

NATURE, 2012, 488 (7413) :642-646

[6]

Anthony DW, 2007, HORSE, THE WHEEL, AND LANGUAGE: HOW BRONZE-AGE RIDERS FROM THE EURASIAN STEPPES SHAPED THE MODERN WORLD, P1

[7] Median-joining networks for inferring intraspecific phylogenies [J].

Bandelt, HJ ;

Forster, P ;

Röhl, A .

MOLECULAR BIOLOGY AND EVOLUTION, 1999, 16 (01) :37-48

[8]

Bastian F, 2008, LECT N BIOINFORMAT, V5109, P124, DOI 10.1007/978-3-540-69828-9_12

[9] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[10]

BOKONYI S, 1968, AM SCH PREHISTORIC R, V25, P3

← 1 2 3 4 5 6 7 8 9 10 →